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Association Analysis of Genetic Variants with Type 2 Diabetes in a Mongolian Population in China
The large scale genome wide association studies (GWAS) have identified approximately 80 single nucleotide polymorphisms (SNPs) conferring susceptibility to type 2 diabetes (T2D). However, most of these loci have not been replicated in diverse populations and much genetic heterogeneity has been obser...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4531200/ https://www.ncbi.nlm.nih.gov/pubmed/26290879 http://dx.doi.org/10.1155/2015/613236 |
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author | Bai, Haihua Liu, Haiping Suyalatu, Suyalatu Guo, Xiaosen Chu, Shandan Chen, Ying Lan, Tianming Borjigin, Burenbatu Orlov, Yuriy L. Posukh, Olga L. Yang, Xiuqin Guilan, Guilan Osipova, Ludmila P. Wu, Qizhu Narisu, Narisu |
author_facet | Bai, Haihua Liu, Haiping Suyalatu, Suyalatu Guo, Xiaosen Chu, Shandan Chen, Ying Lan, Tianming Borjigin, Burenbatu Orlov, Yuriy L. Posukh, Olga L. Yang, Xiuqin Guilan, Guilan Osipova, Ludmila P. Wu, Qizhu Narisu, Narisu |
author_sort | Bai, Haihua |
collection | PubMed |
description | The large scale genome wide association studies (GWAS) have identified approximately 80 single nucleotide polymorphisms (SNPs) conferring susceptibility to type 2 diabetes (T2D). However, most of these loci have not been replicated in diverse populations and much genetic heterogeneity has been observed across ethnic groups. We tested 28 SNPs previously found to be associated with T2D by GWAS in a Mongolian sample of Northern China (497 diagnosed with T2D and 469 controls) for association with T2D and diabetes related quantitative traits. We replicated T2D association of 11 SNPs, namely, rs7578326 (IRS1), rs1531343 (HMGA2), rs8042680 (PRC1), rs7578597 (THADA), rs1333051 (CDKN2), rs6723108 (TMEM163), rs163182 and rs2237897 (KCNQ1), rs1387153 (MTNR1B), rs243021 (BCL11A), and rs10229583 (PAX4) in our sample. Further, we showed that risk allele of the strongest T2D associated SNP in our sample, rs757832 (IRS1), is associated with increased level of TG. We observed substantial difference of T2D risk allele frequency between the Mongolian sample and the 1000G Caucasian sample for a few SNPs, including rs6723108 (TMEM163) whose risk allele reaches near fixation in the Mongolian sample. Further study of genetic architecture of these variants in susceptibility of T2D is needed to understand the role of these variants in heterogeneous populations. |
format | Online Article Text |
id | pubmed-4531200 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-45312002015-08-19 Association Analysis of Genetic Variants with Type 2 Diabetes in a Mongolian Population in China Bai, Haihua Liu, Haiping Suyalatu, Suyalatu Guo, Xiaosen Chu, Shandan Chen, Ying Lan, Tianming Borjigin, Burenbatu Orlov, Yuriy L. Posukh, Olga L. Yang, Xiuqin Guilan, Guilan Osipova, Ludmila P. Wu, Qizhu Narisu, Narisu J Diabetes Res Research Article The large scale genome wide association studies (GWAS) have identified approximately 80 single nucleotide polymorphisms (SNPs) conferring susceptibility to type 2 diabetes (T2D). However, most of these loci have not been replicated in diverse populations and much genetic heterogeneity has been observed across ethnic groups. We tested 28 SNPs previously found to be associated with T2D by GWAS in a Mongolian sample of Northern China (497 diagnosed with T2D and 469 controls) for association with T2D and diabetes related quantitative traits. We replicated T2D association of 11 SNPs, namely, rs7578326 (IRS1), rs1531343 (HMGA2), rs8042680 (PRC1), rs7578597 (THADA), rs1333051 (CDKN2), rs6723108 (TMEM163), rs163182 and rs2237897 (KCNQ1), rs1387153 (MTNR1B), rs243021 (BCL11A), and rs10229583 (PAX4) in our sample. Further, we showed that risk allele of the strongest T2D associated SNP in our sample, rs757832 (IRS1), is associated with increased level of TG. We observed substantial difference of T2D risk allele frequency between the Mongolian sample and the 1000G Caucasian sample for a few SNPs, including rs6723108 (TMEM163) whose risk allele reaches near fixation in the Mongolian sample. Further study of genetic architecture of these variants in susceptibility of T2D is needed to understand the role of these variants in heterogeneous populations. Hindawi Publishing Corporation 2015 2015-07-28 /pmc/articles/PMC4531200/ /pubmed/26290879 http://dx.doi.org/10.1155/2015/613236 Text en Copyright © 2015 Haihua Bai et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Bai, Haihua Liu, Haiping Suyalatu, Suyalatu Guo, Xiaosen Chu, Shandan Chen, Ying Lan, Tianming Borjigin, Burenbatu Orlov, Yuriy L. Posukh, Olga L. Yang, Xiuqin Guilan, Guilan Osipova, Ludmila P. Wu, Qizhu Narisu, Narisu Association Analysis of Genetic Variants with Type 2 Diabetes in a Mongolian Population in China |
title | Association Analysis of Genetic Variants with Type 2 Diabetes in a Mongolian Population in China |
title_full | Association Analysis of Genetic Variants with Type 2 Diabetes in a Mongolian Population in China |
title_fullStr | Association Analysis of Genetic Variants with Type 2 Diabetes in a Mongolian Population in China |
title_full_unstemmed | Association Analysis of Genetic Variants with Type 2 Diabetes in a Mongolian Population in China |
title_short | Association Analysis of Genetic Variants with Type 2 Diabetes in a Mongolian Population in China |
title_sort | association analysis of genetic variants with type 2 diabetes in a mongolian population in china |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4531200/ https://www.ncbi.nlm.nih.gov/pubmed/26290879 http://dx.doi.org/10.1155/2015/613236 |
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