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Strategic internal covalent cross-linking of TNF produces a stable TNF trimer with improved TNFR2 signaling

BACKGROUND: Soluble TNF superfamily (TNFSF) ligands are less stable and less active than their transmembrane (tm) analogues. This is a problem for the therapeutic use of recombinant TNFSF ligands in diverse diseases including cancer and autoimmunity. Creating TNFSF ligand analogues with improved tar...

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Detalles Bibliográficos
Autores principales:	Ban, Liqin, Kuhtreiber, Willem, Butterworth, John, Okubo, Yoshiaki, Vanamee, Éva S., Faustman, Denise L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Short Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4531505/ https://www.ncbi.nlm.nih.gov/pubmed/26266038 http://dx.doi.org/10.1186/s40591-015-0044-4

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