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A Case of Severe Protein-losing Enteropathy as a Late Complication of Pelvic Irradiation

Protein-losing enteropathy is the manifestation of a diverse set of disorders, and it is characterized by the excessive loss of plasma proteins into the affected portions of the gastrointestinal tract, and this results in hypoalbuminemia. We report here on a case of severe protein-losing enteropathy...

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Autores principales: Sohn, Wee Sik, Kim, Duck Ryung, Lee, Jong Sin, Cheon, Gi Jeong, Lee, Byung-Hee, Lee, Seung-Sook, Jeong, Sook-Hyang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Association of Internal Medicine 2004
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4531575/
https://www.ncbi.nlm.nih.gov/pubmed/15683118
http://dx.doi.org/10.3904/kjim.2004.19.4.271
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author Sohn, Wee Sik
Kim, Duck Ryung
Lee, Jong Sin
Cheon, Gi Jeong
Lee, Byung-Hee
Lee, Seung-Sook
Jeong, Sook-Hyang
author_facet Sohn, Wee Sik
Kim, Duck Ryung
Lee, Jong Sin
Cheon, Gi Jeong
Lee, Byung-Hee
Lee, Seung-Sook
Jeong, Sook-Hyang
author_sort Sohn, Wee Sik
collection PubMed
description Protein-losing enteropathy is the manifestation of a diverse set of disorders, and it is characterized by the excessive loss of plasma proteins into the affected portions of the gastrointestinal tract, and this results in hypoalbuminemia. We report here on a case of severe protein-losing enteropathy with the typical clinical features of hypoalbuminemia, dependent edema and increased alpha 1-antitrypsin (α1-AT) clearance, as measured by using 24hr stool testing. The associated disorder with the protein-losing enteropathy of our case was radiation enterocolitis and lymphatic obstruction that was due to radiation treatment and lymph node dissection in the remote past for the treatment of uterine cervical carcinoma. Our case suggests that chronic radiation enterocolitis can result in irreversible injury to the intestinal mucosa and a protein-losing enteropathy, which can bring about a very poor quality of life and even the loss of life.
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spelling pubmed-45315752015-10-02 A Case of Severe Protein-losing Enteropathy as a Late Complication of Pelvic Irradiation Sohn, Wee Sik Kim, Duck Ryung Lee, Jong Sin Cheon, Gi Jeong Lee, Byung-Hee Lee, Seung-Sook Jeong, Sook-Hyang Korean J Intern Med Case Report Protein-losing enteropathy is the manifestation of a diverse set of disorders, and it is characterized by the excessive loss of plasma proteins into the affected portions of the gastrointestinal tract, and this results in hypoalbuminemia. We report here on a case of severe protein-losing enteropathy with the typical clinical features of hypoalbuminemia, dependent edema and increased alpha 1-antitrypsin (α1-AT) clearance, as measured by using 24hr stool testing. The associated disorder with the protein-losing enteropathy of our case was radiation enterocolitis and lymphatic obstruction that was due to radiation treatment and lymph node dissection in the remote past for the treatment of uterine cervical carcinoma. Our case suggests that chronic radiation enterocolitis can result in irreversible injury to the intestinal mucosa and a protein-losing enteropathy, which can bring about a very poor quality of life and even the loss of life. Korean Association of Internal Medicine 2004-12 /pmc/articles/PMC4531575/ /pubmed/15683118 http://dx.doi.org/10.3904/kjim.2004.19.4.271 Text en Copyright © 2004 The Korean Association of Internal Medicine This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Sohn, Wee Sik
Kim, Duck Ryung
Lee, Jong Sin
Cheon, Gi Jeong
Lee, Byung-Hee
Lee, Seung-Sook
Jeong, Sook-Hyang
A Case of Severe Protein-losing Enteropathy as a Late Complication of Pelvic Irradiation
title A Case of Severe Protein-losing Enteropathy as a Late Complication of Pelvic Irradiation
title_full A Case of Severe Protein-losing Enteropathy as a Late Complication of Pelvic Irradiation
title_fullStr A Case of Severe Protein-losing Enteropathy as a Late Complication of Pelvic Irradiation
title_full_unstemmed A Case of Severe Protein-losing Enteropathy as a Late Complication of Pelvic Irradiation
title_short A Case of Severe Protein-losing Enteropathy as a Late Complication of Pelvic Irradiation
title_sort case of severe protein-losing enteropathy as a late complication of pelvic irradiation
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4531575/
https://www.ncbi.nlm.nih.gov/pubmed/15683118
http://dx.doi.org/10.3904/kjim.2004.19.4.271
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