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Postoperative Findings and Risk for Malignancy in Thyroid Nodules with Cytological Diagnosis of the so-called “Follicular Neoplasm”
BACKGROUND : Malignant follicular lesion is not differentiated from benign lesions cytologically. The objective of this study was to assess the rate and the risk of malignancy in thyroid nodules which were cytologically diagnosed as follicular neoplasm by fine-needle aspiration (FNA) cytology. METHO...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Korean Association of Internal Medicine
2003
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4531614/ https://www.ncbi.nlm.nih.gov/pubmed/12872446 http://dx.doi.org/10.3904/kjim.2003.18.2.94 |
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author | Kim, Eun Sook Nam-Goong, Il Seong Gong, Gyungyub Hong, Suck Joon Kim, Won Bae Shong, Young Kee |
author_facet | Kim, Eun Sook Nam-Goong, Il Seong Gong, Gyungyub Hong, Suck Joon Kim, Won Bae Shong, Young Kee |
author_sort | Kim, Eun Sook |
collection | PubMed |
description | BACKGROUND : Malignant follicular lesion is not differentiated from benign lesions cytologically. The objective of this study was to assess the rate and the risk of malignancy in thyroid nodules which were cytologically diagnosed as follicular neoplasm by fine-needle aspiration (FNA) cytology. METHODS : All the patients who had undergone surgery with cytological diagnosis of follicular neoplasm from January 1996 through December 2001 in Asan Medical Center were studied retrospectively. Patients’ and nodule characteristics were analyzed for factors associated with the presence of cancer. Two hundred and fifteen patients (196 females, 19 males) were included and their mean age was 39.4 years (range: 12–76). RESULTS : About half of the patients (102 out of 215, 47.4%) had malignancy with 29 papillary carcinomas, 57 follicular carcinomas, 15 Hürthle cell carcinomas and 1 medullary carcinoma. Previously suggested factors associated with risk for malignancy, such as male gender, large tumor size (>4 cm) or age of patients (>45 years), were not associated with increased risk. Diagnosis of Hürthle cell neoplasia on FNA was also not associated with increased risk. Only the extremes in age of the patients (below 20 or above 60 years) were associated with increased risk for malignancy. CONCLUSION : In our findings, prevalence of carcinoma in thyroid nodule patients with cytological diagnosis of follicular neoplasm was much higher than those reported. Clinical characteristics, such as male gender, age and nodule size, are not useful predictors for the presence of malignancy. Thyroid nodules with cytological diagnosis of follicular neoplasm warrant immediate surgery. |
format | Online Article Text |
id | pubmed-4531614 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2003 |
publisher | Korean Association of Internal Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-45316142015-10-02 Postoperative Findings and Risk for Malignancy in Thyroid Nodules with Cytological Diagnosis of the so-called “Follicular Neoplasm” Kim, Eun Sook Nam-Goong, Il Seong Gong, Gyungyub Hong, Suck Joon Kim, Won Bae Shong, Young Kee Korean J Intern Med Original Article BACKGROUND : Malignant follicular lesion is not differentiated from benign lesions cytologically. The objective of this study was to assess the rate and the risk of malignancy in thyroid nodules which were cytologically diagnosed as follicular neoplasm by fine-needle aspiration (FNA) cytology. METHODS : All the patients who had undergone surgery with cytological diagnosis of follicular neoplasm from January 1996 through December 2001 in Asan Medical Center were studied retrospectively. Patients’ and nodule characteristics were analyzed for factors associated with the presence of cancer. Two hundred and fifteen patients (196 females, 19 males) were included and their mean age was 39.4 years (range: 12–76). RESULTS : About half of the patients (102 out of 215, 47.4%) had malignancy with 29 papillary carcinomas, 57 follicular carcinomas, 15 Hürthle cell carcinomas and 1 medullary carcinoma. Previously suggested factors associated with risk for malignancy, such as male gender, large tumor size (>4 cm) or age of patients (>45 years), were not associated with increased risk. Diagnosis of Hürthle cell neoplasia on FNA was also not associated with increased risk. Only the extremes in age of the patients (below 20 or above 60 years) were associated with increased risk for malignancy. CONCLUSION : In our findings, prevalence of carcinoma in thyroid nodule patients with cytological diagnosis of follicular neoplasm was much higher than those reported. Clinical characteristics, such as male gender, age and nodule size, are not useful predictors for the presence of malignancy. Thyroid nodules with cytological diagnosis of follicular neoplasm warrant immediate surgery. Korean Association of Internal Medicine 2003-06 /pmc/articles/PMC4531614/ /pubmed/12872446 http://dx.doi.org/10.3904/kjim.2003.18.2.94 Text en Copyright © 2003 The Korean Association of Internal Medicine This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Kim, Eun Sook Nam-Goong, Il Seong Gong, Gyungyub Hong, Suck Joon Kim, Won Bae Shong, Young Kee Postoperative Findings and Risk for Malignancy in Thyroid Nodules with Cytological Diagnosis of the so-called “Follicular Neoplasm” |
title | Postoperative Findings and Risk for Malignancy in Thyroid Nodules with Cytological Diagnosis of the so-called “Follicular Neoplasm” |
title_full | Postoperative Findings and Risk for Malignancy in Thyroid Nodules with Cytological Diagnosis of the so-called “Follicular Neoplasm” |
title_fullStr | Postoperative Findings and Risk for Malignancy in Thyroid Nodules with Cytological Diagnosis of the so-called “Follicular Neoplasm” |
title_full_unstemmed | Postoperative Findings and Risk for Malignancy in Thyroid Nodules with Cytological Diagnosis of the so-called “Follicular Neoplasm” |
title_short | Postoperative Findings and Risk for Malignancy in Thyroid Nodules with Cytological Diagnosis of the so-called “Follicular Neoplasm” |
title_sort | postoperative findings and risk for malignancy in thyroid nodules with cytological diagnosis of the so-called “follicular neoplasm” |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4531614/ https://www.ncbi.nlm.nih.gov/pubmed/12872446 http://dx.doi.org/10.3904/kjim.2003.18.2.94 |
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