A Case of Neurotoxicity Following 5-Fluorouracil-based Chemotherapy

5-Fluorouracil (5-FU) is a commonly used chemotherapeutic agent. However, its neurotoxicity is rare and not well recognized. We report a case of 5-FU neurotoxicity with organic brain syndrome and progression to multifocal leukoencephalopathy in a 44-year-old male patient having malignant gastrointes...

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Autores principales: Ki, Seung Seog, Jeong, Jin Mo, Kim, Seong Ho, Jeong, Sook Hyang, Lee, Jin Hyuk, Han, Chul Ju, Kim, You Cheol, Lee, Jhin Oh, Hong, Young Joon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Association of Internal Medicine 2002
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4531646/
https://www.ncbi.nlm.nih.gov/pubmed/12014219
http://dx.doi.org/10.3904/kjim.2002.17.1.73
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author Ki, Seung Seog
Jeong, Jin Mo
Kim, Seong Ho
Jeong, Sook Hyang
Lee, Jin Hyuk
Han, Chul Ju
Kim, You Cheol
Lee, Jhin Oh
Hong, Young Joon
author_facet Ki, Seung Seog
Jeong, Jin Mo
Kim, Seong Ho
Jeong, Sook Hyang
Lee, Jin Hyuk
Han, Chul Ju
Kim, You Cheol
Lee, Jhin Oh
Hong, Young Joon
author_sort Ki, Seung Seog
collection PubMed
description 5-Fluorouracil (5-FU) is a commonly used chemotherapeutic agent. However, its neurotoxicity is rare and not well recognized. We report a case of 5-FU neurotoxicity with organic brain syndrome and progression to multifocal leukoencephalopathy in a 44-year-old male patient having malignant gastrointestinal stromal tumor. 5-FU-induced neurotoxicity should, therefore, be considered as an important differential diagnosis in cancer patients with neurological abnormality and history of chemotherapy.
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spelling pubmed-45316462015-10-02 A Case of Neurotoxicity Following 5-Fluorouracil-based Chemotherapy Ki, Seung Seog Jeong, Jin Mo Kim, Seong Ho Jeong, Sook Hyang Lee, Jin Hyuk Han, Chul Ju Kim, You Cheol Lee, Jhin Oh Hong, Young Joon Korean J Intern Med Case Report 5-Fluorouracil (5-FU) is a commonly used chemotherapeutic agent. However, its neurotoxicity is rare and not well recognized. We report a case of 5-FU neurotoxicity with organic brain syndrome and progression to multifocal leukoencephalopathy in a 44-year-old male patient having malignant gastrointestinal stromal tumor. 5-FU-induced neurotoxicity should, therefore, be considered as an important differential diagnosis in cancer patients with neurological abnormality and history of chemotherapy. Korean Association of Internal Medicine 2002-03 /pmc/articles/PMC4531646/ /pubmed/12014219 http://dx.doi.org/10.3904/kjim.2002.17.1.73 Text en Copyright © 2002 The Korean Association of Internal Medicine This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Ki, Seung Seog
Jeong, Jin Mo
Kim, Seong Ho
Jeong, Sook Hyang
Lee, Jin Hyuk
Han, Chul Ju
Kim, You Cheol
Lee, Jhin Oh
Hong, Young Joon
A Case of Neurotoxicity Following 5-Fluorouracil-based Chemotherapy
title A Case of Neurotoxicity Following 5-Fluorouracil-based Chemotherapy
title_full A Case of Neurotoxicity Following 5-Fluorouracil-based Chemotherapy
title_fullStr A Case of Neurotoxicity Following 5-Fluorouracil-based Chemotherapy
title_full_unstemmed A Case of Neurotoxicity Following 5-Fluorouracil-based Chemotherapy
title_short A Case of Neurotoxicity Following 5-Fluorouracil-based Chemotherapy
title_sort case of neurotoxicity following 5-fluorouracil-based chemotherapy
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4531646/
https://www.ncbi.nlm.nih.gov/pubmed/12014219
http://dx.doi.org/10.3904/kjim.2002.17.1.73
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