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Clinical Significance of Anti-endothelial Cell Antibody in Renal Transplant Recipients
In order to evaluate the role of anti-endothelial cell antibody (AECA) in acute rejection in renal transplantation, serum AECA IgG titers were measured in 68 healthy controls, 111 chronic hemodialysis (HD) patients and 58 first renal transplant recipients. The AECA titer in hemodialysis patients was...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Korean Association of Internal Medicine
2001
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4531702/ https://www.ncbi.nlm.nih.gov/pubmed/11417301 http://dx.doi.org/10.3904/kjim.2001.16.1.24 |
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author | Shin, Young Shin Yang, Chul Woo Ahn, Hee Jong Park, Cheol Whee Jin, Dong Chan Kim, Yong Soo Chang, Yoon Sik Bang, Byung Kee |
author_facet | Shin, Young Shin Yang, Chul Woo Ahn, Hee Jong Park, Cheol Whee Jin, Dong Chan Kim, Yong Soo Chang, Yoon Sik Bang, Byung Kee |
author_sort | Shin, Young Shin |
collection | PubMed |
description | In order to evaluate the role of anti-endothelial cell antibody (AECA) in acute rejection in renal transplantation, serum AECA IgG titers were measured in 68 healthy controls, 111 chronic hemodialysis (HD) patients and 58 first renal transplant recipients. The AECA titer in hemodialysis patients was higher than in healthy controls (13.9 ± 5.0 vs. 4.8 ± 2.3 U/mL, p<0.01). In transplant recipients, AECA titers were not affected by dialysis mode (HD vs. CAPD vs. non-dialysis ; 9.6 ± 7.6 vs. 7.9 ± 3.9 vs. 11.9 ± 3.1 U/mL, p>0.05). After renal transplantation, AECA titer was decreased significantly (vs. 4.7 ± 3.6 U/mL, p<0.01). The serum AECA IgG titers increased significantly in recipients with acute rejection (6.9 ± 3.1 vs. 13.5 ± 9.9 U/mL, p<0.01), but decreased to 5.6 ± 3.0 U/mL (p<0.01) after formal rejection therapy. In the recipients with acute rejection (n=27), the pre-renal transplant AECA titer was higher than in that without acute rejection (14.0 ± 8.6 vs. 7.7 ± 3.8 U/mL, p<0.01). The results of this study lead us to conclude that pre- and post-renal transplant AECA titer might be a useful predictor for acute rejection and useful for monitoring acute rejection in renal transplant recipients. |
format | Online Article Text |
id | pubmed-4531702 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2001 |
publisher | Korean Association of Internal Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-45317022015-10-02 Clinical Significance of Anti-endothelial Cell Antibody in Renal Transplant Recipients Shin, Young Shin Yang, Chul Woo Ahn, Hee Jong Park, Cheol Whee Jin, Dong Chan Kim, Yong Soo Chang, Yoon Sik Bang, Byung Kee Korean J Intern Med Original Article In order to evaluate the role of anti-endothelial cell antibody (AECA) in acute rejection in renal transplantation, serum AECA IgG titers were measured in 68 healthy controls, 111 chronic hemodialysis (HD) patients and 58 first renal transplant recipients. The AECA titer in hemodialysis patients was higher than in healthy controls (13.9 ± 5.0 vs. 4.8 ± 2.3 U/mL, p<0.01). In transplant recipients, AECA titers were not affected by dialysis mode (HD vs. CAPD vs. non-dialysis ; 9.6 ± 7.6 vs. 7.9 ± 3.9 vs. 11.9 ± 3.1 U/mL, p>0.05). After renal transplantation, AECA titer was decreased significantly (vs. 4.7 ± 3.6 U/mL, p<0.01). The serum AECA IgG titers increased significantly in recipients with acute rejection (6.9 ± 3.1 vs. 13.5 ± 9.9 U/mL, p<0.01), but decreased to 5.6 ± 3.0 U/mL (p<0.01) after formal rejection therapy. In the recipients with acute rejection (n=27), the pre-renal transplant AECA titer was higher than in that without acute rejection (14.0 ± 8.6 vs. 7.7 ± 3.8 U/mL, p<0.01). The results of this study lead us to conclude that pre- and post-renal transplant AECA titer might be a useful predictor for acute rejection and useful for monitoring acute rejection in renal transplant recipients. Korean Association of Internal Medicine 2001-03 /pmc/articles/PMC4531702/ /pubmed/11417301 http://dx.doi.org/10.3904/kjim.2001.16.1.24 Text en Copyright © 2001 The Korean Association of Internal Medicine This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Shin, Young Shin Yang, Chul Woo Ahn, Hee Jong Park, Cheol Whee Jin, Dong Chan Kim, Yong Soo Chang, Yoon Sik Bang, Byung Kee Clinical Significance of Anti-endothelial Cell Antibody in Renal Transplant Recipients |
title | Clinical Significance of Anti-endothelial Cell Antibody in Renal Transplant Recipients |
title_full | Clinical Significance of Anti-endothelial Cell Antibody in Renal Transplant Recipients |
title_fullStr | Clinical Significance of Anti-endothelial Cell Antibody in Renal Transplant Recipients |
title_full_unstemmed | Clinical Significance of Anti-endothelial Cell Antibody in Renal Transplant Recipients |
title_short | Clinical Significance of Anti-endothelial Cell Antibody in Renal Transplant Recipients |
title_sort | clinical significance of anti-endothelial cell antibody in renal transplant recipients |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4531702/ https://www.ncbi.nlm.nih.gov/pubmed/11417301 http://dx.doi.org/10.3904/kjim.2001.16.1.24 |
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