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The Effect of Cilostazol on Glucose Tolerance and Insulin Resistance in a Rat Model of Non-insulin Dependent Diabetes Mellitus

BACKGROUND: it has been reported that many peripheral vasodilating drugs might improve insulin resistance. Cilostazol, a antithrombotic agent, increases peripheral blood flow in non-insulin dependent diabetic patients. The effect of cilostazol treatment on insulin resistance in streptozotocin (STZ)-...

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Autores principales: Chang, Sang Ah, Cha, Bong Yun, Yoo, Soon Jib, Ahn, Yoo Bae, Song, Ki Ho, Han, Je Ho, Lee, Jong Min, Son, Hyun Sik, Yoon, Kun Ho, Kang, Moo IL, Lee, Kwang Woo, Son, Ho Young, Kang, Sung Ku
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Association of Internal Medicine 2001
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4531709/
https://www.ncbi.nlm.nih.gov/pubmed/11590907
http://dx.doi.org/10.3904/kjim.2001.16.2.87
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author Chang, Sang Ah
Cha, Bong Yun
Yoo, Soon Jib
Ahn, Yoo Bae
Song, Ki Ho
Han, Je Ho
Lee, Jong Min
Son, Hyun Sik
Yoon, Kun Ho
Kang, Moo IL
Lee, Kwang Woo
Son, Ho Young
Kang, Sung Ku
author_facet Chang, Sang Ah
Cha, Bong Yun
Yoo, Soon Jib
Ahn, Yoo Bae
Song, Ki Ho
Han, Je Ho
Lee, Jong Min
Son, Hyun Sik
Yoon, Kun Ho
Kang, Moo IL
Lee, Kwang Woo
Son, Ho Young
Kang, Sung Ku
author_sort Chang, Sang Ah
collection PubMed
description BACKGROUND: it has been reported that many peripheral vasodilating drugs might improve insulin resistance. Cilostazol, a antithrombotic agent, increases peripheral blood flow in non-insulin dependent diabetic patients. The effect of cilostazol treatment on insulin resistance in streptozotocin (STZ)-induced non-insulin dependent diabetic Wistar rats was examined. METHODS: About a half of two-day old neonate siblings were injected intraperitoneally with STZ and maintained for six months, at which time they were compared with age-matched control rats for intraperitoneal glucose tolerance test (IPGTT) and for glucose infusion rate (GINF) in a euglycemic hyperinsulinemic glucose-clamp study. After that, these studies were also performed after feeding rat chow containing cilostazol (100 mg/kg/day) to rats with STZ-induced non-insulin dependent diabetes mellitus for four-weeks and compared with those of age-matched control rats. RESULTS: In the intraperitoneal glucose tolerance test studies, plasma glucose levels of STZ-induced non-insulin dependent diabetic rats were significantly higher and plasma insulin levels significantly lower than those of age-matched control rats in the age of six months. Glucose infusion rate was lower in STZ-induced non-insulin dependent diabetic rats than those of age-matched control rats. However, after a four-week cilostazol treatment, glucose infusion rate of STZ-induced non-insulin dependent diabetic rats was not significantly different from that of control rats. CONCLUSION: These findings suggested that cilostazol may improve insulin resistance in STZ-induced non-insulin dependent diabetic rats.
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spelling pubmed-45317092015-10-02 The Effect of Cilostazol on Glucose Tolerance and Insulin Resistance in a Rat Model of Non-insulin Dependent Diabetes Mellitus Chang, Sang Ah Cha, Bong Yun Yoo, Soon Jib Ahn, Yoo Bae Song, Ki Ho Han, Je Ho Lee, Jong Min Son, Hyun Sik Yoon, Kun Ho Kang, Moo IL Lee, Kwang Woo Son, Ho Young Kang, Sung Ku Korean J Intern Med Original Article BACKGROUND: it has been reported that many peripheral vasodilating drugs might improve insulin resistance. Cilostazol, a antithrombotic agent, increases peripheral blood flow in non-insulin dependent diabetic patients. The effect of cilostazol treatment on insulin resistance in streptozotocin (STZ)-induced non-insulin dependent diabetic Wistar rats was examined. METHODS: About a half of two-day old neonate siblings were injected intraperitoneally with STZ and maintained for six months, at which time they were compared with age-matched control rats for intraperitoneal glucose tolerance test (IPGTT) and for glucose infusion rate (GINF) in a euglycemic hyperinsulinemic glucose-clamp study. After that, these studies were also performed after feeding rat chow containing cilostazol (100 mg/kg/day) to rats with STZ-induced non-insulin dependent diabetes mellitus for four-weeks and compared with those of age-matched control rats. RESULTS: In the intraperitoneal glucose tolerance test studies, plasma glucose levels of STZ-induced non-insulin dependent diabetic rats were significantly higher and plasma insulin levels significantly lower than those of age-matched control rats in the age of six months. Glucose infusion rate was lower in STZ-induced non-insulin dependent diabetic rats than those of age-matched control rats. However, after a four-week cilostazol treatment, glucose infusion rate of STZ-induced non-insulin dependent diabetic rats was not significantly different from that of control rats. CONCLUSION: These findings suggested that cilostazol may improve insulin resistance in STZ-induced non-insulin dependent diabetic rats. Korean Association of Internal Medicine 2001-06 /pmc/articles/PMC4531709/ /pubmed/11590907 http://dx.doi.org/10.3904/kjim.2001.16.2.87 Text en Copyright © 2001 The Korean Association of Internal Medicine This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Chang, Sang Ah
Cha, Bong Yun
Yoo, Soon Jib
Ahn, Yoo Bae
Song, Ki Ho
Han, Je Ho
Lee, Jong Min
Son, Hyun Sik
Yoon, Kun Ho
Kang, Moo IL
Lee, Kwang Woo
Son, Ho Young
Kang, Sung Ku
The Effect of Cilostazol on Glucose Tolerance and Insulin Resistance in a Rat Model of Non-insulin Dependent Diabetes Mellitus
title The Effect of Cilostazol on Glucose Tolerance and Insulin Resistance in a Rat Model of Non-insulin Dependent Diabetes Mellitus
title_full The Effect of Cilostazol on Glucose Tolerance and Insulin Resistance in a Rat Model of Non-insulin Dependent Diabetes Mellitus
title_fullStr The Effect of Cilostazol on Glucose Tolerance and Insulin Resistance in a Rat Model of Non-insulin Dependent Diabetes Mellitus
title_full_unstemmed The Effect of Cilostazol on Glucose Tolerance and Insulin Resistance in a Rat Model of Non-insulin Dependent Diabetes Mellitus
title_short The Effect of Cilostazol on Glucose Tolerance and Insulin Resistance in a Rat Model of Non-insulin Dependent Diabetes Mellitus
title_sort effect of cilostazol on glucose tolerance and insulin resistance in a rat model of non-insulin dependent diabetes mellitus
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4531709/
https://www.ncbi.nlm.nih.gov/pubmed/11590907
http://dx.doi.org/10.3904/kjim.2001.16.2.87
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