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Modulatory effect of semelil (ANGIPARS™) on isoproterenol induced cardiac injury

Administration of semelil (ANGIPARS™) has been successful in the treatment of diabetic foot ulcer. Considering the improvement of blood flow and anti-inflammatory effect that are attributed to this drug, we investigated its effect on cardiovascular performance in rabbits with isoproterenol (ISO) ind...

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Autores principales: Joukar, Siyavash, Najafipour, Hamid, Mirzaeipour, Fateme, Nasri, Hamidreza, Ahmadi, Mahboubeh Yeganeh Haj, Badinloo, Marziyeh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Leibniz Research Centre for Working Environment and Human Factors 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4531780/
https://www.ncbi.nlm.nih.gov/pubmed/26417221
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author Joukar, Siyavash
Najafipour, Hamid
Mirzaeipour, Fateme
Nasri, Hamidreza
Ahmadi, Mahboubeh Yeganeh Haj
Badinloo, Marziyeh
author_facet Joukar, Siyavash
Najafipour, Hamid
Mirzaeipour, Fateme
Nasri, Hamidreza
Ahmadi, Mahboubeh Yeganeh Haj
Badinloo, Marziyeh
author_sort Joukar, Siyavash
collection PubMed
description Administration of semelil (ANGIPARS™) has been successful in the treatment of diabetic foot ulcer. Considering the improvement of blood flow and anti-inflammatory effect that are attributed to this drug, we investigated its effect on cardiovascular performance in rabbits with isoproterenol (ISO) induced myocardial injury. Animal groups included: control group; ISO group, received ISO 50 mg/kg s.c. for two consecutive days; S1+ISO, S5+ISO and S10+ISO groups, received semelil 1, 5, and 10 mg/kg/day i.p. respectively, 30 min before ISO. On the 3(rd) day, electrocardiogram (ECG) and hemodynamic parameters were recorded; blood samples were taken and hearts were removed for lab investigations. ISO induced heart injury, ECG disturbance, raise of cardiac troponin I and significant decrease in LVSP (p<0.05), +dp/dt max (p<0.01), -dp/dt max (p<0.05) along with increase of LVEDP (p<0.01). Semelil had no significant effects on ECG and plasma cardiac troponin I. Impairment of +dp/dt max and -dp/dt max was significantly improved in S5+ISO and S10+ISO groups (P<0.05 versus ISO). In addition, LVSP and LVEDP was somewhat recovered in these groups, although semelil (1 mg/kg/day) to some extent exacerbated the myocardial lesions induced by ISO (P<0.05). Therefore, in stressful conditions, semelil may improve myocardial contractility; however, it may aggravate the severity of injury.
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spelling pubmed-45317802015-09-28 Modulatory effect of semelil (ANGIPARS™) on isoproterenol induced cardiac injury Joukar, Siyavash Najafipour, Hamid Mirzaeipour, Fateme Nasri, Hamidreza Ahmadi, Mahboubeh Yeganeh Haj Badinloo, Marziyeh EXCLI J Original Article Administration of semelil (ANGIPARS™) has been successful in the treatment of diabetic foot ulcer. Considering the improvement of blood flow and anti-inflammatory effect that are attributed to this drug, we investigated its effect on cardiovascular performance in rabbits with isoproterenol (ISO) induced myocardial injury. Animal groups included: control group; ISO group, received ISO 50 mg/kg s.c. for two consecutive days; S1+ISO, S5+ISO and S10+ISO groups, received semelil 1, 5, and 10 mg/kg/day i.p. respectively, 30 min before ISO. On the 3(rd) day, electrocardiogram (ECG) and hemodynamic parameters were recorded; blood samples were taken and hearts were removed for lab investigations. ISO induced heart injury, ECG disturbance, raise of cardiac troponin I and significant decrease in LVSP (p<0.05), +dp/dt max (p<0.01), -dp/dt max (p<0.05) along with increase of LVEDP (p<0.01). Semelil had no significant effects on ECG and plasma cardiac troponin I. Impairment of +dp/dt max and -dp/dt max was significantly improved in S5+ISO and S10+ISO groups (P<0.05 versus ISO). In addition, LVSP and LVEDP was somewhat recovered in these groups, although semelil (1 mg/kg/day) to some extent exacerbated the myocardial lesions induced by ISO (P<0.05). Therefore, in stressful conditions, semelil may improve myocardial contractility; however, it may aggravate the severity of injury. Leibniz Research Centre for Working Environment and Human Factors 2013-02-19 /pmc/articles/PMC4531780/ /pubmed/26417221 Text en Copyright © 2013 Joukar et al. http://www.excli.de/documents/assignment_of_rights.pdf This is an Open Access article distributed under the following Assignment of Rights http://www.excli.de/documents/assignment_of_rights.pdf. You are free to copy, distribute and transmit the work, provided the original author and source are credited.
spellingShingle Original Article
Joukar, Siyavash
Najafipour, Hamid
Mirzaeipour, Fateme
Nasri, Hamidreza
Ahmadi, Mahboubeh Yeganeh Haj
Badinloo, Marziyeh
Modulatory effect of semelil (ANGIPARS™) on isoproterenol induced cardiac injury
title Modulatory effect of semelil (ANGIPARS™) on isoproterenol induced cardiac injury
title_full Modulatory effect of semelil (ANGIPARS™) on isoproterenol induced cardiac injury
title_fullStr Modulatory effect of semelil (ANGIPARS™) on isoproterenol induced cardiac injury
title_full_unstemmed Modulatory effect of semelil (ANGIPARS™) on isoproterenol induced cardiac injury
title_short Modulatory effect of semelil (ANGIPARS™) on isoproterenol induced cardiac injury
title_sort modulatory effect of semelil (angipars™) on isoproterenol induced cardiac injury
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4531780/
https://www.ncbi.nlm.nih.gov/pubmed/26417221
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