Cargando…
Modulatory effect of semelil (ANGIPARS™) on isoproterenol induced cardiac injury
Administration of semelil (ANGIPARS™) has been successful in the treatment of diabetic foot ulcer. Considering the improvement of blood flow and anti-inflammatory effect that are attributed to this drug, we investigated its effect on cardiovascular performance in rabbits with isoproterenol (ISO) ind...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Leibniz Research Centre for Working Environment and Human Factors
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4531780/ https://www.ncbi.nlm.nih.gov/pubmed/26417221 |
_version_ | 1782385113438355456 |
---|---|
author | Joukar, Siyavash Najafipour, Hamid Mirzaeipour, Fateme Nasri, Hamidreza Ahmadi, Mahboubeh Yeganeh Haj Badinloo, Marziyeh |
author_facet | Joukar, Siyavash Najafipour, Hamid Mirzaeipour, Fateme Nasri, Hamidreza Ahmadi, Mahboubeh Yeganeh Haj Badinloo, Marziyeh |
author_sort | Joukar, Siyavash |
collection | PubMed |
description | Administration of semelil (ANGIPARS™) has been successful in the treatment of diabetic foot ulcer. Considering the improvement of blood flow and anti-inflammatory effect that are attributed to this drug, we investigated its effect on cardiovascular performance in rabbits with isoproterenol (ISO) induced myocardial injury. Animal groups included: control group; ISO group, received ISO 50 mg/kg s.c. for two consecutive days; S1+ISO, S5+ISO and S10+ISO groups, received semelil 1, 5, and 10 mg/kg/day i.p. respectively, 30 min before ISO. On the 3(rd) day, electrocardiogram (ECG) and hemodynamic parameters were recorded; blood samples were taken and hearts were removed for lab investigations. ISO induced heart injury, ECG disturbance, raise of cardiac troponin I and significant decrease in LVSP (p<0.05), +dp/dt max (p<0.01), -dp/dt max (p<0.05) along with increase of LVEDP (p<0.01). Semelil had no significant effects on ECG and plasma cardiac troponin I. Impairment of +dp/dt max and -dp/dt max was significantly improved in S5+ISO and S10+ISO groups (P<0.05 versus ISO). In addition, LVSP and LVEDP was somewhat recovered in these groups, although semelil (1 mg/kg/day) to some extent exacerbated the myocardial lesions induced by ISO (P<0.05). Therefore, in stressful conditions, semelil may improve myocardial contractility; however, it may aggravate the severity of injury. |
format | Online Article Text |
id | pubmed-4531780 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Leibniz Research Centre for Working Environment and Human Factors |
record_format | MEDLINE/PubMed |
spelling | pubmed-45317802015-09-28 Modulatory effect of semelil (ANGIPARS™) on isoproterenol induced cardiac injury Joukar, Siyavash Najafipour, Hamid Mirzaeipour, Fateme Nasri, Hamidreza Ahmadi, Mahboubeh Yeganeh Haj Badinloo, Marziyeh EXCLI J Original Article Administration of semelil (ANGIPARS™) has been successful in the treatment of diabetic foot ulcer. Considering the improvement of blood flow and anti-inflammatory effect that are attributed to this drug, we investigated its effect on cardiovascular performance in rabbits with isoproterenol (ISO) induced myocardial injury. Animal groups included: control group; ISO group, received ISO 50 mg/kg s.c. for two consecutive days; S1+ISO, S5+ISO and S10+ISO groups, received semelil 1, 5, and 10 mg/kg/day i.p. respectively, 30 min before ISO. On the 3(rd) day, electrocardiogram (ECG) and hemodynamic parameters were recorded; blood samples were taken and hearts were removed for lab investigations. ISO induced heart injury, ECG disturbance, raise of cardiac troponin I and significant decrease in LVSP (p<0.05), +dp/dt max (p<0.01), -dp/dt max (p<0.05) along with increase of LVEDP (p<0.01). Semelil had no significant effects on ECG and plasma cardiac troponin I. Impairment of +dp/dt max and -dp/dt max was significantly improved in S5+ISO and S10+ISO groups (P<0.05 versus ISO). In addition, LVSP and LVEDP was somewhat recovered in these groups, although semelil (1 mg/kg/day) to some extent exacerbated the myocardial lesions induced by ISO (P<0.05). Therefore, in stressful conditions, semelil may improve myocardial contractility; however, it may aggravate the severity of injury. Leibniz Research Centre for Working Environment and Human Factors 2013-02-19 /pmc/articles/PMC4531780/ /pubmed/26417221 Text en Copyright © 2013 Joukar et al. http://www.excli.de/documents/assignment_of_rights.pdf This is an Open Access article distributed under the following Assignment of Rights http://www.excli.de/documents/assignment_of_rights.pdf. You are free to copy, distribute and transmit the work, provided the original author and source are credited. |
spellingShingle | Original Article Joukar, Siyavash Najafipour, Hamid Mirzaeipour, Fateme Nasri, Hamidreza Ahmadi, Mahboubeh Yeganeh Haj Badinloo, Marziyeh Modulatory effect of semelil (ANGIPARS™) on isoproterenol induced cardiac injury |
title | Modulatory effect of semelil (ANGIPARS™) on isoproterenol induced cardiac injury |
title_full | Modulatory effect of semelil (ANGIPARS™) on isoproterenol induced cardiac injury |
title_fullStr | Modulatory effect of semelil (ANGIPARS™) on isoproterenol induced cardiac injury |
title_full_unstemmed | Modulatory effect of semelil (ANGIPARS™) on isoproterenol induced cardiac injury |
title_short | Modulatory effect of semelil (ANGIPARS™) on isoproterenol induced cardiac injury |
title_sort | modulatory effect of semelil (angipars™) on isoproterenol induced cardiac injury |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4531780/ https://www.ncbi.nlm.nih.gov/pubmed/26417221 |
work_keys_str_mv | AT joukarsiyavash modulatoryeffectofsemelilangiparsonisoproterenolinducedcardiacinjury AT najafipourhamid modulatoryeffectofsemelilangiparsonisoproterenolinducedcardiacinjury AT mirzaeipourfateme modulatoryeffectofsemelilangiparsonisoproterenolinducedcardiacinjury AT nasrihamidreza modulatoryeffectofsemelilangiparsonisoproterenolinducedcardiacinjury AT ahmadimahboubehyeganehhaj modulatoryeffectofsemelilangiparsonisoproterenolinducedcardiacinjury AT badinloomarziyeh modulatoryeffectofsemelilangiparsonisoproterenolinducedcardiacinjury |