Seven weeks of Western diet in apolipoprotein-E-deficient mice induce metabolic syndrome and non-alcoholic steatohepatitis with liver fibrosis

Non-alcoholic steatohepatitis (NASH) is characterised by hepatic steatosis, inflammation and fibrosis, which might progress to cirrhosis. Human NASH is associated with metabolic syndrome (MS). Currently, rodent NASH models either lack significant fibrosis or MS. ApoE(−/−) mice are a MS model used in...

Descripción completa

Detalles Bibliográficos
Autores principales: Schierwagen, Robert, Maybüchen, Lara, Zimmer, Sebastian, Hittatiya, Kanishka, Bäck, Christer, Klein, Sabine, Uschner, Frank E., Reul, Winfried, Boor, Peter, Nickenig, Georg, Strassburg, Christian P., Trautwein, Christian, Plat, Jogchum, Lütjohann, Dieter, Sauerbruch, Tilman, Tacke, Frank, Trebicka, Jonel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4531783/
https://www.ncbi.nlm.nih.gov/pubmed/26263022
http://dx.doi.org/10.1038/srep12931

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4531783/
https://www.ncbi.nlm.nih.gov/pubmed/26263022
http://dx.doi.org/10.1038/srep12931

Ejemplares similares