Acute exacerbations of chronic obstructive pulmonary disease are associated with decreased CD4+ & CD8+ T cells and increased growth & differentiation factor-15 (GDF-15) in peripheral blood

BACKGROUND: Although T cells, especially CD8+, have been implicated in chronic obstructive pulmonary disease (COPD) pathogenesis, their role during acute exacerbations (AE-COPD) is uncertain. METHODS: We recruited subjects with COPD and a history of previous AE-COPD and studied them quarterly to col...

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Detalles Bibliográficos
Autores principales: Freeman, Christine M., Martinez, Carlos H., Todt, Jill C., Martinez, Fernando J., Han, MeiLan K., Thompson, Deborah L., McCloskey, Lisa, Curtis, Jeffrey L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4531816/
https://www.ncbi.nlm.nih.gov/pubmed/26243260
http://dx.doi.org/10.1186/s12931-015-0251-1

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