Next-Generation o-Nitrobenzyl Photolabile Groups for Light-Directed Chemistry and Microarray Synthesis**

Light as an external trigger is a valuable and easily controllable tool for directing chemical reactions with high spatial and temporal accuracy. Two o-nitrobenzyl derivatives, benzoyl- and thiophenyl-NPPOC, undergo photo-deprotection with significantly improved efficiency over that of the commonly...

Descripción completa

Detalles Bibliográficos
Autores principales: Kretschy, Nicole, Holik, Ann-Katrin, Somoza, Veronika, Stengele, Klaus-Peter, Somoza, Mark M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: WILEY-VCH Verlag 2015
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4531821/
https://www.ncbi.nlm.nih.gov/pubmed/26036777
http://dx.doi.org/10.1002/anie.201502125
_version_ 1782385122448769024
author Kretschy, Nicole
Holik, Ann-Katrin
Somoza, Veronika
Stengele, Klaus-Peter
Somoza, Mark M
author_facet Kretschy, Nicole
Holik, Ann-Katrin
Somoza, Veronika
Stengele, Klaus-Peter
Somoza, Mark M
author_sort Kretschy, Nicole
collection PubMed
description Light as an external trigger is a valuable and easily controllable tool for directing chemical reactions with high spatial and temporal accuracy. Two o-nitrobenzyl derivatives, benzoyl- and thiophenyl-NPPOC, undergo photo-deprotection with significantly improved efficiency over that of the commonly used NPPOC group. The two- and twelvefold increase in photo-deprotection efficiency was proven using photolithograph synthesis of microarrays.
format Online
Article
Text
id pubmed-4531821
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher WILEY-VCH Verlag
record_format MEDLINE/PubMed
spelling pubmed-45318212015-08-15 Next-Generation o-Nitrobenzyl Photolabile Groups for Light-Directed Chemistry and Microarray Synthesis** Kretschy, Nicole Holik, Ann-Katrin Somoza, Veronika Stengele, Klaus-Peter Somoza, Mark M Angew Chem Int Ed Engl Communications Light as an external trigger is a valuable and easily controllable tool for directing chemical reactions with high spatial and temporal accuracy. Two o-nitrobenzyl derivatives, benzoyl- and thiophenyl-NPPOC, undergo photo-deprotection with significantly improved efficiency over that of the commonly used NPPOC group. The two- and twelvefold increase in photo-deprotection efficiency was proven using photolithograph synthesis of microarrays. WILEY-VCH Verlag 2015-07-13 2015-06-03 /pmc/articles/PMC4531821/ /pubmed/26036777 http://dx.doi.org/10.1002/anie.201502125 Text en © 2015 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. http://creativecommons.org/licenses/by/4.0/ This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Communications
Kretschy, Nicole
Holik, Ann-Katrin
Somoza, Veronika
Stengele, Klaus-Peter
Somoza, Mark M
Next-Generation o-Nitrobenzyl Photolabile Groups for Light-Directed Chemistry and Microarray Synthesis**
title Next-Generation o-Nitrobenzyl Photolabile Groups for Light-Directed Chemistry and Microarray Synthesis**
title_full Next-Generation o-Nitrobenzyl Photolabile Groups for Light-Directed Chemistry and Microarray Synthesis**
title_fullStr Next-Generation o-Nitrobenzyl Photolabile Groups for Light-Directed Chemistry and Microarray Synthesis**
title_full_unstemmed Next-Generation o-Nitrobenzyl Photolabile Groups for Light-Directed Chemistry and Microarray Synthesis**
title_short Next-Generation o-Nitrobenzyl Photolabile Groups for Light-Directed Chemistry and Microarray Synthesis**
title_sort next-generation o-nitrobenzyl photolabile groups for light-directed chemistry and microarray synthesis**
topic Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4531821/
https://www.ncbi.nlm.nih.gov/pubmed/26036777
http://dx.doi.org/10.1002/anie.201502125
work_keys_str_mv AT kretschynicole nextgenerationonitrobenzylphotolabilegroupsforlightdirectedchemistryandmicroarraysynthesis
AT holikannkatrin nextgenerationonitrobenzylphotolabilegroupsforlightdirectedchemistryandmicroarraysynthesis
AT somozaveronika nextgenerationonitrobenzylphotolabilegroupsforlightdirectedchemistryandmicroarraysynthesis
AT stengeleklauspeter nextgenerationonitrobenzylphotolabilegroupsforlightdirectedchemistryandmicroarraysynthesis
AT somozamarkm nextgenerationonitrobenzylphotolabilegroupsforlightdirectedchemistryandmicroarraysynthesis

Ejemplares similares