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Effect of Helicobacter pylori infection on antral gastrin and somatostatin cells and on serum gastrin concentrations

OBJECTIVES: Helicobacter pylori infection induces selective reduction of the number of antral D-cells and results in abnormal regulation of serum gastrin secretion. The purpose of this study was to investigate the relationship between H. pylori infection and the numbers of G-cells and D-cells. METHO...

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Autores principales: Park, Sill Moo, Lee, Hyo Rang, Kim, Jae Gyu, Park, Joong Won, Jung, Gyu, Han, Seong Hyuck, Cho, Joon Hyung, Kim, Mi Kyung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Association of Internal Medicine 1999
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4531904/
https://www.ncbi.nlm.nih.gov/pubmed/10063309
http://dx.doi.org/10.3904/kjim.1999.14.1.15
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author Park, Sill Moo
Lee, Hyo Rang
Kim, Jae Gyu
Park, Joong Won
Jung, Gyu
Han, Seong Hyuck
Cho, Joon Hyung
Kim, Mi Kyung
author_facet Park, Sill Moo
Lee, Hyo Rang
Kim, Jae Gyu
Park, Joong Won
Jung, Gyu
Han, Seong Hyuck
Cho, Joon Hyung
Kim, Mi Kyung
author_sort Park, Sill Moo
collection PubMed
description OBJECTIVES: Helicobacter pylori infection induces selective reduction of the number of antral D-cells and results in abnormal regulation of serum gastrin secretion. The purpose of this study was to investigate the relationship between H. pylori infection and the numbers of G-cells and D-cells. METHODS: The numbers of antral G-cells and D-cells, the ratio of G-cells to D-cells and fasting serum gastrin concentrations were compared between 37 patients with (29 with duodenal ulcers and 8 with gastric ulcers) and 33 without H. pylori infection (22 with duodenal ulcers and 11 with gastric ulcers). Serum gastrin concentrations were measured using the radioimmunoassay technique. Antral mucosal biopsy specimens were examined using immunohistochemical staining with antibodies specific for gastrin and somatostatin and the numbers of G-cells and D-cells per gastric gland were counted. RESULTS: Fasting serum gastrin concentrations were significantly higher in patients with H. pylori infection compared to patients without infection (80.3±23.5 vs 47.6±14.1 pg/ml, p<0.001). The number of G-cells per gastric gland was similar in infected and uninfected patients (7.1±3.1 vs 7.3±3.9, respectively, p>0.5). The number of D-cells was significantly lower in patients with H. pylori infection than in uninfected patients in both duodenal and gastric ulcer patients (1.3±0.4 vs 2.5±1.6, respectively, p<0.001). The ratio of G-cells to D-cells was also significantly higher in infected patients compared with uninfected patients for both gastric and duodenal ulcers (5.7±2.7 vs 3.5±1.9, respectively, p<0.001). CONCLUSIONS: These results strongly suggest that Helicobacter pylori infection induces reduction of the number of antral D-cells. The resulting relative hypofunction of the inhibitory action of D-cells against G-cells may be responsible for increased serum gastrin secretion.
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spelling pubmed-45319042015-10-02 Effect of Helicobacter pylori infection on antral gastrin and somatostatin cells and on serum gastrin concentrations Park, Sill Moo Lee, Hyo Rang Kim, Jae Gyu Park, Joong Won Jung, Gyu Han, Seong Hyuck Cho, Joon Hyung Kim, Mi Kyung Korean J Intern Med Original Article OBJECTIVES: Helicobacter pylori infection induces selective reduction of the number of antral D-cells and results in abnormal regulation of serum gastrin secretion. The purpose of this study was to investigate the relationship between H. pylori infection and the numbers of G-cells and D-cells. METHODS: The numbers of antral G-cells and D-cells, the ratio of G-cells to D-cells and fasting serum gastrin concentrations were compared between 37 patients with (29 with duodenal ulcers and 8 with gastric ulcers) and 33 without H. pylori infection (22 with duodenal ulcers and 11 with gastric ulcers). Serum gastrin concentrations were measured using the radioimmunoassay technique. Antral mucosal biopsy specimens were examined using immunohistochemical staining with antibodies specific for gastrin and somatostatin and the numbers of G-cells and D-cells per gastric gland were counted. RESULTS: Fasting serum gastrin concentrations were significantly higher in patients with H. pylori infection compared to patients without infection (80.3±23.5 vs 47.6±14.1 pg/ml, p<0.001). The number of G-cells per gastric gland was similar in infected and uninfected patients (7.1±3.1 vs 7.3±3.9, respectively, p>0.5). The number of D-cells was significantly lower in patients with H. pylori infection than in uninfected patients in both duodenal and gastric ulcer patients (1.3±0.4 vs 2.5±1.6, respectively, p<0.001). The ratio of G-cells to D-cells was also significantly higher in infected patients compared with uninfected patients for both gastric and duodenal ulcers (5.7±2.7 vs 3.5±1.9, respectively, p<0.001). CONCLUSIONS: These results strongly suggest that Helicobacter pylori infection induces reduction of the number of antral D-cells. The resulting relative hypofunction of the inhibitory action of D-cells against G-cells may be responsible for increased serum gastrin secretion. Korean Association of Internal Medicine 1999-01 /pmc/articles/PMC4531904/ /pubmed/10063309 http://dx.doi.org/10.3904/kjim.1999.14.1.15 Text en Copyright © 1999 The Korean Association of Internal Medicine This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Park, Sill Moo
Lee, Hyo Rang
Kim, Jae Gyu
Park, Joong Won
Jung, Gyu
Han, Seong Hyuck
Cho, Joon Hyung
Kim, Mi Kyung
Effect of Helicobacter pylori infection on antral gastrin and somatostatin cells and on serum gastrin concentrations
title Effect of Helicobacter pylori infection on antral gastrin and somatostatin cells and on serum gastrin concentrations
title_full Effect of Helicobacter pylori infection on antral gastrin and somatostatin cells and on serum gastrin concentrations
title_fullStr Effect of Helicobacter pylori infection on antral gastrin and somatostatin cells and on serum gastrin concentrations
title_full_unstemmed Effect of Helicobacter pylori infection on antral gastrin and somatostatin cells and on serum gastrin concentrations
title_short Effect of Helicobacter pylori infection on antral gastrin and somatostatin cells and on serum gastrin concentrations
title_sort effect of helicobacter pylori infection on antral gastrin and somatostatin cells and on serum gastrin concentrations
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4531904/
https://www.ncbi.nlm.nih.gov/pubmed/10063309
http://dx.doi.org/10.3904/kjim.1999.14.1.15
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