A Case of Marfan Syndrome with Acute Monoblastic Leukemia

We report on an 18-year-old man who had both acute monoblastic leukemia and Marfan syndrome. A diagnosis of Marfan syndrome was established by those characteristics of arachnodactyly, ectopia lentis, mitral valve prolapse, and mitral regurgitation. Findings on bone marrow examination of the patient...

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Autores principales: Lee, Je Jung, Kim, Hyeoung Joon, Chung, Ik Joo, Jeong, Myung Ho, Kook, Hoon, Seo, Jea Sung, Kim, Nam Jin, Park, Moo Rim, Choi, Kyeoung Sang, Hwang, Tai Ju
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Association of Internal Medicine 1998
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4531946/
https://www.ncbi.nlm.nih.gov/pubmed/9735672
http://dx.doi.org/10.3904/kjim.1998.13.2.140
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author Lee, Je Jung
Kim, Hyeoung Joon
Chung, Ik Joo
Jeong, Myung Ho
Kook, Hoon
Seo, Jea Sung
Kim, Nam Jin
Park, Moo Rim
Choi, Kyeoung Sang
Hwang, Tai Ju
author_facet Lee, Je Jung
Kim, Hyeoung Joon
Chung, Ik Joo
Jeong, Myung Ho
Kook, Hoon
Seo, Jea Sung
Kim, Nam Jin
Park, Moo Rim
Choi, Kyeoung Sang
Hwang, Tai Ju
author_sort Lee, Je Jung
collection PubMed
description We report on an 18-year-old man who had both acute monoblastic leukemia and Marfan syndrome. A diagnosis of Marfan syndrome was established by those characteristics of arachnodactyly, ectopia lentis, mitral valve prolapse, and mitral regurgitation. Findings on bone marrow examination of the patient showed that most of nucleated cells were monoblasts and immunophenotype of those cells showed CD13+, CD33+, CD56+, and HLA-DH+. To our knowledge, this is the second report of leukemia in Marfan syndrome in the world.
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spelling pubmed-45319462015-10-02 A Case of Marfan Syndrome with Acute Monoblastic Leukemia Lee, Je Jung Kim, Hyeoung Joon Chung, Ik Joo Jeong, Myung Ho Kook, Hoon Seo, Jea Sung Kim, Nam Jin Park, Moo Rim Choi, Kyeoung Sang Hwang, Tai Ju Korean J Intern Med Case Report We report on an 18-year-old man who had both acute monoblastic leukemia and Marfan syndrome. A diagnosis of Marfan syndrome was established by those characteristics of arachnodactyly, ectopia lentis, mitral valve prolapse, and mitral regurgitation. Findings on bone marrow examination of the patient showed that most of nucleated cells were monoblasts and immunophenotype of those cells showed CD13+, CD33+, CD56+, and HLA-DH+. To our knowledge, this is the second report of leukemia in Marfan syndrome in the world. Korean Association of Internal Medicine 1998-07 /pmc/articles/PMC4531946/ /pubmed/9735672 http://dx.doi.org/10.3904/kjim.1998.13.2.140 Text en Copyright © 1998 The Korean Association of Internal Medicine This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Lee, Je Jung
Kim, Hyeoung Joon
Chung, Ik Joo
Jeong, Myung Ho
Kook, Hoon
Seo, Jea Sung
Kim, Nam Jin
Park, Moo Rim
Choi, Kyeoung Sang
Hwang, Tai Ju
A Case of Marfan Syndrome with Acute Monoblastic Leukemia
title A Case of Marfan Syndrome with Acute Monoblastic Leukemia
title_full A Case of Marfan Syndrome with Acute Monoblastic Leukemia
title_fullStr A Case of Marfan Syndrome with Acute Monoblastic Leukemia
title_full_unstemmed A Case of Marfan Syndrome with Acute Monoblastic Leukemia
title_short A Case of Marfan Syndrome with Acute Monoblastic Leukemia
title_sort case of marfan syndrome with acute monoblastic leukemia
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4531946/
https://www.ncbi.nlm.nih.gov/pubmed/9735672
http://dx.doi.org/10.3904/kjim.1998.13.2.140
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