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Differences in Immunophenotyping of Mucosal Lymphocytes Between Ulcerative Colitis and Crohn’s Disease
OBJECTIVES: Immunologic studies have characterized the numbers and types of inflammatory cells in diseased inflammatory bowel disease (IBD) mucosa but have yielded conflicting results regarding intestinal lymphocytes activation in IBD. We investigated the levels of lymphocytes subsets, interieukin-2...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Association of Internal Medicine
1997
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4531961/ https://www.ncbi.nlm.nih.gov/pubmed/9159031 http://dx.doi.org/10.3904/kjim.1997.12.1.7 |
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author | Lee, Heung Bum Kim, Jong Hun Yim, Chang Yeol Kim, Dae Ghon Ahn, Deuk Soo |
author_facet | Lee, Heung Bum Kim, Jong Hun Yim, Chang Yeol Kim, Dae Ghon Ahn, Deuk Soo |
author_sort | Lee, Heung Bum |
collection | PubMed |
description | OBJECTIVES: Immunologic studies have characterized the numbers and types of inflammatory cells in diseased inflammatory bowel disease (IBD) mucosa but have yielded conflicting results regarding intestinal lymphocytes activation in IBD. We investigated the levels of lymphocytes subsets, interieukin-2 receptor, transferrin receptor, and T cell receptors in mainly isolated lamina propria lymphocytes, including intraepithelial lymphocytes of normal colonic mucosa or IBD (ulcerative colitis and Crohn’s disease) mucosa to understand the pathogenesis of IBD. We have results from this study. RESULTS: 1) In comparing ulcerative colitis with control, IL-2R (p<0.05), TR (p<0.01), and CD3/HLA-DR (p<0.05) showed a significant increase. 2) In comparing Crohn’s disease with control, CD3 (p<0.05), TCR α/β (p<0.01) and TCR γ/δ (p<0.05) showed a significant decrease. 3) In comparing Crohn’s disease with ulcerative colitis, CD19 (p<0.01), TR (p< 0.01), TCR α/β (p<0.01) and TCR γ/δ (p<0.05) showed a significant decrease. CONCLUSION: From these results, there are increased T cell markers, IL-2R, TR, and CD3/HLA-DR in UC, but differently, decreased CD3, TCR α/β and TCR γ/δ in CD compared with control. In addition, definitive differences in lymphocytes markers, CD19, TR, TCR α/β and TCR γ/δ, which are higher in UC than in CD, may elucidate the different immunopathogenesis between UC and CD. |
format | Online Article Text |
id | pubmed-4531961 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1997 |
publisher | Korean Association of Internal Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-45319612015-10-02 Differences in Immunophenotyping of Mucosal Lymphocytes Between Ulcerative Colitis and Crohn’s Disease Lee, Heung Bum Kim, Jong Hun Yim, Chang Yeol Kim, Dae Ghon Ahn, Deuk Soo Korean J Intern Med Original Article OBJECTIVES: Immunologic studies have characterized the numbers and types of inflammatory cells in diseased inflammatory bowel disease (IBD) mucosa but have yielded conflicting results regarding intestinal lymphocytes activation in IBD. We investigated the levels of lymphocytes subsets, interieukin-2 receptor, transferrin receptor, and T cell receptors in mainly isolated lamina propria lymphocytes, including intraepithelial lymphocytes of normal colonic mucosa or IBD (ulcerative colitis and Crohn’s disease) mucosa to understand the pathogenesis of IBD. We have results from this study. RESULTS: 1) In comparing ulcerative colitis with control, IL-2R (p<0.05), TR (p<0.01), and CD3/HLA-DR (p<0.05) showed a significant increase. 2) In comparing Crohn’s disease with control, CD3 (p<0.05), TCR α/β (p<0.01) and TCR γ/δ (p<0.05) showed a significant decrease. 3) In comparing Crohn’s disease with ulcerative colitis, CD19 (p<0.01), TR (p< 0.01), TCR α/β (p<0.01) and TCR γ/δ (p<0.05) showed a significant decrease. CONCLUSION: From these results, there are increased T cell markers, IL-2R, TR, and CD3/HLA-DR in UC, but differently, decreased CD3, TCR α/β and TCR γ/δ in CD compared with control. In addition, definitive differences in lymphocytes markers, CD19, TR, TCR α/β and TCR γ/δ, which are higher in UC than in CD, may elucidate the different immunopathogenesis between UC and CD. Korean Association of Internal Medicine 1997-01 /pmc/articles/PMC4531961/ /pubmed/9159031 http://dx.doi.org/10.3904/kjim.1997.12.1.7 Text en Copyright © 1997 The Korean Association of Internal Medicine This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Lee, Heung Bum Kim, Jong Hun Yim, Chang Yeol Kim, Dae Ghon Ahn, Deuk Soo Differences in Immunophenotyping of Mucosal Lymphocytes Between Ulcerative Colitis and Crohn’s Disease |
title | Differences in Immunophenotyping of Mucosal Lymphocytes Between Ulcerative Colitis and Crohn’s Disease |
title_full | Differences in Immunophenotyping of Mucosal Lymphocytes Between Ulcerative Colitis and Crohn’s Disease |
title_fullStr | Differences in Immunophenotyping of Mucosal Lymphocytes Between Ulcerative Colitis and Crohn’s Disease |
title_full_unstemmed | Differences in Immunophenotyping of Mucosal Lymphocytes Between Ulcerative Colitis and Crohn’s Disease |
title_short | Differences in Immunophenotyping of Mucosal Lymphocytes Between Ulcerative Colitis and Crohn’s Disease |
title_sort | differences in immunophenotyping of mucosal lymphocytes between ulcerative colitis and crohn’s disease |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4531961/ https://www.ncbi.nlm.nih.gov/pubmed/9159031 http://dx.doi.org/10.3904/kjim.1997.12.1.7 |
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