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Acute Pyelonephritis Focusing on Perfusion Defects on Contrast Enhansed Computerized Tomography(CT) Scans and Its Clinical Outcome
OBJECTIVES: Many cases of acute pyelonephritis show renal perfusion defects on contrast enhanced computerized tomography (CT) imaging studies. The purpose of this study is to show the frequency of renal perfusion defects in uncomplicated acute pyelonephritis and to compare the clinical responses of...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Korean Association of Internal Medicine
1997
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4531993/ https://www.ncbi.nlm.nih.gov/pubmed/9439146 http://dx.doi.org/10.3904/kjim.1997.12.2.122 |
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author | Ha, Sung-Kyu Seo, Jung-Kun Kim, Seung-Jung Park, Seung-Ho Park, Chong-Hoon Lee, Ho-Yung Han, Dae-Suk Kim, Ki-Whang |
author_facet | Ha, Sung-Kyu Seo, Jung-Kun Kim, Seung-Jung Park, Seung-Ho Park, Chong-Hoon Lee, Ho-Yung Han, Dae-Suk Kim, Ki-Whang |
author_sort | Ha, Sung-Kyu |
collection | PubMed |
description | OBJECTIVES: Many cases of acute pyelonephritis show renal perfusion defects on contrast enhanced computerized tomography (CT) imaging studies. The purpose of this study is to show the frequency of renal perfusion defects in uncomplicated acute pyelonephritis and to compare the clinical responses of patients who had perfusion defects or not. METHODS: We studied patients who had symptoms and signs of acute pyelonephritis through CT examinations with contrast enhancement. We identified 21 cases who had perfusion defects among 35 patients who had undergone CT imaging studies and compared the clinical data in the two groups of patients who had perfusion defects on CT (group 1) and who had not (group 2). RESULTS: Nearly all patients had typical symptoms and signs of acute pyelonephritis such as high fever and chill, flank pain and costovertebral angle tenderness. Combined clinical problems were septic shock (one case, 4.8%) and disseminated intravascular coagulation (DIC) (one case, 4.8%) in group 1. Laboratory findings were not different between the two groups. All patients were treated with antibiotics and had successful recoveries. The duration of recovery of pyuria in group 1 (5.2±9.6 days) was not longer than that in group 2(3.1±2.9 days) (p>0.05). The length of defeverscence in group 1 (7.0±4.6 days) was longer than in group 2 (3.5±2.7 days) (p<0.05). There were no differences between group 1 and group 2 in the rate of predisposing factors. Thirteen of 21 cases (61.9%) in group 1 and five of 14 cases (35.7%) in group 2 had positive urine culture results which are relatively low probably due to the administration of antibiotics prior to our emergency room visit. Perfusion defects on CT were very frequent findings (60.0% of the clinical acute pyelonephritis patients). We classified CT findings of group 1 as focal unilateral (2 cases, 9.5%), multifocal unilateral (14 cases, 66.7%) and multifocal bilateral (5 cases, 23.8%), and there were no differences between the subgroups of group 1 in the duration of defeverscence. CONCLUSION: Those patients who had perfusion defects on CT showed relatively severe clinical courses but responses to early antibiotics were very good. Contrast enhanced CT scans may be very sensitive for the detection of acute renal parenchymal inflammatory disease and for defining the extent of disease, but it is clinically not essential to perform in the early uncomplicated acute pyelonephritis because CT diagnosis does not change management. Clinical use of contrast enhanced CT scan may be appropriate in case of persistence of fever and leukocytosis for more than seven days despite antibiotic treatment. |
format | Online Article Text |
id | pubmed-4531993 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1997 |
publisher | Korean Association of Internal Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-45319932015-10-02 Acute Pyelonephritis Focusing on Perfusion Defects on Contrast Enhansed Computerized Tomography(CT) Scans and Its Clinical Outcome Ha, Sung-Kyu Seo, Jung-Kun Kim, Seung-Jung Park, Seung-Ho Park, Chong-Hoon Lee, Ho-Yung Han, Dae-Suk Kim, Ki-Whang Korean J Intern Med Original Article OBJECTIVES: Many cases of acute pyelonephritis show renal perfusion defects on contrast enhanced computerized tomography (CT) imaging studies. The purpose of this study is to show the frequency of renal perfusion defects in uncomplicated acute pyelonephritis and to compare the clinical responses of patients who had perfusion defects or not. METHODS: We studied patients who had symptoms and signs of acute pyelonephritis through CT examinations with contrast enhancement. We identified 21 cases who had perfusion defects among 35 patients who had undergone CT imaging studies and compared the clinical data in the two groups of patients who had perfusion defects on CT (group 1) and who had not (group 2). RESULTS: Nearly all patients had typical symptoms and signs of acute pyelonephritis such as high fever and chill, flank pain and costovertebral angle tenderness. Combined clinical problems were septic shock (one case, 4.8%) and disseminated intravascular coagulation (DIC) (one case, 4.8%) in group 1. Laboratory findings were not different between the two groups. All patients were treated with antibiotics and had successful recoveries. The duration of recovery of pyuria in group 1 (5.2±9.6 days) was not longer than that in group 2(3.1±2.9 days) (p>0.05). The length of defeverscence in group 1 (7.0±4.6 days) was longer than in group 2 (3.5±2.7 days) (p<0.05). There were no differences between group 1 and group 2 in the rate of predisposing factors. Thirteen of 21 cases (61.9%) in group 1 and five of 14 cases (35.7%) in group 2 had positive urine culture results which are relatively low probably due to the administration of antibiotics prior to our emergency room visit. Perfusion defects on CT were very frequent findings (60.0% of the clinical acute pyelonephritis patients). We classified CT findings of group 1 as focal unilateral (2 cases, 9.5%), multifocal unilateral (14 cases, 66.7%) and multifocal bilateral (5 cases, 23.8%), and there were no differences between the subgroups of group 1 in the duration of defeverscence. CONCLUSION: Those patients who had perfusion defects on CT showed relatively severe clinical courses but responses to early antibiotics were very good. Contrast enhanced CT scans may be very sensitive for the detection of acute renal parenchymal inflammatory disease and for defining the extent of disease, but it is clinically not essential to perform in the early uncomplicated acute pyelonephritis because CT diagnosis does not change management. Clinical use of contrast enhanced CT scan may be appropriate in case of persistence of fever and leukocytosis for more than seven days despite antibiotic treatment. Korean Association of Internal Medicine 1997-06 /pmc/articles/PMC4531993/ /pubmed/9439146 http://dx.doi.org/10.3904/kjim.1997.12.2.122 Text en Copyright © 1997 The Korean Association of Internal Medicine This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Ha, Sung-Kyu Seo, Jung-Kun Kim, Seung-Jung Park, Seung-Ho Park, Chong-Hoon Lee, Ho-Yung Han, Dae-Suk Kim, Ki-Whang Acute Pyelonephritis Focusing on Perfusion Defects on Contrast Enhansed Computerized Tomography(CT) Scans and Its Clinical Outcome |
title | Acute Pyelonephritis Focusing on Perfusion Defects on Contrast Enhansed Computerized Tomography(CT) Scans and Its Clinical Outcome |
title_full | Acute Pyelonephritis Focusing on Perfusion Defects on Contrast Enhansed Computerized Tomography(CT) Scans and Its Clinical Outcome |
title_fullStr | Acute Pyelonephritis Focusing on Perfusion Defects on Contrast Enhansed Computerized Tomography(CT) Scans and Its Clinical Outcome |
title_full_unstemmed | Acute Pyelonephritis Focusing on Perfusion Defects on Contrast Enhansed Computerized Tomography(CT) Scans and Its Clinical Outcome |
title_short | Acute Pyelonephritis Focusing on Perfusion Defects on Contrast Enhansed Computerized Tomography(CT) Scans and Its Clinical Outcome |
title_sort | acute pyelonephritis focusing on perfusion defects on contrast enhansed computerized tomography(ct) scans and its clinical outcome |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4531993/ https://www.ncbi.nlm.nih.gov/pubmed/9439146 http://dx.doi.org/10.3904/kjim.1997.12.2.122 |
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