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Nonspecific Interstitial Pneumonia/Fibrosis: Clinical Manifestations, Histologic and Radiologic Features

OBJECTIVES: Customarily used classification of IPF did not satisfy a sizable group of patients with IPF that in the past had been lumped with UIP and now currently has begun to be recognized as nonspecific interstitial pneumonia/fibrosis (NIP). There are few reports about the clinical features of NI...

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Autores principales: Park, Choon Sik, Jeon, Jin Woo, Park, Sung Woo, Lim, Gune-Il, Jeong, Seong Hwan, Uh, Soo-Taek, Park, Jai Soung, Choi, Deuk Lin, Jin, So Young, Kang, Chang Hee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Association of Internal Medicine 1996
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4532011/
https://www.ncbi.nlm.nih.gov/pubmed/8854648
http://dx.doi.org/10.3904/kjim.1996.11.2.122
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author Park, Choon Sik
Jeon, Jin Woo
Park, Sung Woo
Lim, Gune-Il
Jeong, Seong Hwan
Uh, Soo-Taek
Park, Jai Soung
Choi, Deuk Lin
Jin, So Young
Kang, Chang Hee
author_facet Park, Choon Sik
Jeon, Jin Woo
Park, Sung Woo
Lim, Gune-Il
Jeong, Seong Hwan
Uh, Soo-Taek
Park, Jai Soung
Choi, Deuk Lin
Jin, So Young
Kang, Chang Hee
author_sort Park, Choon Sik
collection PubMed
description OBJECTIVES: Customarily used classification of IPF did not satisfy a sizable group of patients with IPF that in the past had been lumped with UIP and now currently has begun to be recognized as nonspecific interstitial pneumonia/fibrosis (NIP). There are few reports about the clinical features of NIP. METHODS: The pathologic slides of 66 patients having open lung biopsy (OLB) for the differential diagnosis of interstitial lung diseases (ILD) from 1984 to 1995 were reviewed. Seven cases were confirmed as NIP. The clinical record, pulmonay function tests (PFT), chest PA and HRCT were reviewed and analysed retrospectively. RESULTS: Six patients with NIP were female. The median age was 56 years. Mean duration of symptoms was 4 months. Five patients had systemic flu-like symptoms. the most common respiratory symptom was gradual dyspnea Two patients revealed a mild degree of anemia Four cases had leukocytois of more than 10,000/mm(3). ESR and CRP O.K. elevated in all measured cases. Anti-nuclear antibody (ANA) was positive in three of six patients and ds-DNA antibody was positive in one of six patients Restrictive pattern of PFT was predominant. Diffusion capacity of carbonmonoxide (DLCO) decreased markedly. In bronchoalveolar lavage (BAL), total cell counts elevated about three times of normal value. On differntial counts of BAL cells, lymphocytes, neutrophils and eosinophils were higher than those of normal controls. The prominent finding of chest radiology was bilaterally patchy opacifications in parenchyme of lower lung zones. On HRCT, bilaterally patchy areas of ground-glass attenuation and/or areas of alveolar consolidation were commonly shown. The number of pathologic type was one case of group I, four cases of group II and two cases of group III. The average period from diagnosis to the last follow-up was 24.8 months. Five patients were clinically recovered to the previously well-being state. CONCLUSION: Patients with NIP had different clinical features from UIP, AIP and DIP. They also had characteristic findings of radiology and their prognosis seems to be better than UIP.
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spelling pubmed-45320112015-10-02 Nonspecific Interstitial Pneumonia/Fibrosis: Clinical Manifestations, Histologic and Radiologic Features Park, Choon Sik Jeon, Jin Woo Park, Sung Woo Lim, Gune-Il Jeong, Seong Hwan Uh, Soo-Taek Park, Jai Soung Choi, Deuk Lin Jin, So Young Kang, Chang Hee Korean J Intern Med Original Article OBJECTIVES: Customarily used classification of IPF did not satisfy a sizable group of patients with IPF that in the past had been lumped with UIP and now currently has begun to be recognized as nonspecific interstitial pneumonia/fibrosis (NIP). There are few reports about the clinical features of NIP. METHODS: The pathologic slides of 66 patients having open lung biopsy (OLB) for the differential diagnosis of interstitial lung diseases (ILD) from 1984 to 1995 were reviewed. Seven cases were confirmed as NIP. The clinical record, pulmonay function tests (PFT), chest PA and HRCT were reviewed and analysed retrospectively. RESULTS: Six patients with NIP were female. The median age was 56 years. Mean duration of symptoms was 4 months. Five patients had systemic flu-like symptoms. the most common respiratory symptom was gradual dyspnea Two patients revealed a mild degree of anemia Four cases had leukocytois of more than 10,000/mm(3). ESR and CRP O.K. elevated in all measured cases. Anti-nuclear antibody (ANA) was positive in three of six patients and ds-DNA antibody was positive in one of six patients Restrictive pattern of PFT was predominant. Diffusion capacity of carbonmonoxide (DLCO) decreased markedly. In bronchoalveolar lavage (BAL), total cell counts elevated about three times of normal value. On differntial counts of BAL cells, lymphocytes, neutrophils and eosinophils were higher than those of normal controls. The prominent finding of chest radiology was bilaterally patchy opacifications in parenchyme of lower lung zones. On HRCT, bilaterally patchy areas of ground-glass attenuation and/or areas of alveolar consolidation were commonly shown. The number of pathologic type was one case of group I, four cases of group II and two cases of group III. The average period from diagnosis to the last follow-up was 24.8 months. Five patients were clinically recovered to the previously well-being state. CONCLUSION: Patients with NIP had different clinical features from UIP, AIP and DIP. They also had characteristic findings of radiology and their prognosis seems to be better than UIP. Korean Association of Internal Medicine 1996-06 /pmc/articles/PMC4532011/ /pubmed/8854648 http://dx.doi.org/10.3904/kjim.1996.11.2.122 Text en Copyright © 1996 The Korean Association of Internal Medicine This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Park, Choon Sik
Jeon, Jin Woo
Park, Sung Woo
Lim, Gune-Il
Jeong, Seong Hwan
Uh, Soo-Taek
Park, Jai Soung
Choi, Deuk Lin
Jin, So Young
Kang, Chang Hee
Nonspecific Interstitial Pneumonia/Fibrosis: Clinical Manifestations, Histologic and Radiologic Features
title Nonspecific Interstitial Pneumonia/Fibrosis: Clinical Manifestations, Histologic and Radiologic Features
title_full Nonspecific Interstitial Pneumonia/Fibrosis: Clinical Manifestations, Histologic and Radiologic Features
title_fullStr Nonspecific Interstitial Pneumonia/Fibrosis: Clinical Manifestations, Histologic and Radiologic Features
title_full_unstemmed Nonspecific Interstitial Pneumonia/Fibrosis: Clinical Manifestations, Histologic and Radiologic Features
title_short Nonspecific Interstitial Pneumonia/Fibrosis: Clinical Manifestations, Histologic and Radiologic Features
title_sort nonspecific interstitial pneumonia/fibrosis: clinical manifestations, histologic and radiologic features
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4532011/
https://www.ncbi.nlm.nih.gov/pubmed/8854648
http://dx.doi.org/10.3904/kjim.1996.11.2.122
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