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Interferon Alpha Therapy in Patients with Chronic Type C Hepatitis: Changes of Serum ALT, Anti-HCV & HCV-RNA
BACKGROUND: After the discovery of type C hepatitis virus, the studies on this virus are extensively progressing. The treatment of this viral infection is also widely progressing. Among many agents, recombinant interferon alpha therapy is generally accepted as an effective single agent. To evaluate...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Association of Internal Medicine
1992
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4532103/ https://www.ncbi.nlm.nih.gov/pubmed/1282364 http://dx.doi.org/10.3904/kjim.1992.7.1.13 |
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author | Cho, Ho Jun Dong, Seok Ho Lee, Myung Suk Kim, Hak Yang Park, Choong Kee Yoo, Jae Young Polito, Allan Quan, Stella Han, Jang Hyun |
author_facet | Cho, Ho Jun Dong, Seok Ho Lee, Myung Suk Kim, Hak Yang Park, Choong Kee Yoo, Jae Young Polito, Allan Quan, Stella Han, Jang Hyun |
author_sort | Cho, Ho Jun |
collection | PubMed |
description | BACKGROUND: After the discovery of type C hepatitis virus, the studies on this virus are extensively progressing. The treatment of this viral infection is also widely progressing. Among many agents, recombinant interferon alpha therapy is generally accepted as an effective single agent. To evaluate the efficacy of interferon and to observe the changes of serum aminotransferase (ALT), antibody to hepatitis C virus (anti-HCV) and HCV ribonucleic acid (HCV-RNA), we treated 10 patients with chronic type C hepatitis for 6 months. METHODS: Patients were randomly divided into 2 groups: 5 patients in group A received interferon and the other 5 in group B received no therapy. Interferon was administered at a dose of 3 million units (MU) daily for the first month and thrice weekly for the following 5 months, and followed up for 2 years. RESULTS: In group A, serum ALT returned to normal in 4: 3, starting at the first month and one at the 3rd month of therapy and maintained normal throughout the follow-up period. In contrast, serum ALT level persistently fluctuated in 4 patients in group B. In one patient, serum ALT returned to normal one and a half years later. Regardless of therapy, serum anti-HCV titer remained unchanged in all patients. However, HCV-RNA, using polymerized chain reaction (PCR), became undetetable in all responded patients and in one untreated patient whose serum ALT returned to normal spontaneously. CONCLUSION: This study suggested that interferon alpha therapy in patients with chronic type C hepatitis may be clinically effective. Our study also indicated that the detection of HCV-RNA by PCR is useful to predict the prognosis of chronic type C hepatitis. |
format | Online Article Text |
id | pubmed-4532103 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1992 |
publisher | Korean Association of Internal Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-45321032015-10-02 Interferon Alpha Therapy in Patients with Chronic Type C Hepatitis: Changes of Serum ALT, Anti-HCV & HCV-RNA Cho, Ho Jun Dong, Seok Ho Lee, Myung Suk Kim, Hak Yang Park, Choong Kee Yoo, Jae Young Polito, Allan Quan, Stella Han, Jang Hyun Korean J Intern Med Articles BACKGROUND: After the discovery of type C hepatitis virus, the studies on this virus are extensively progressing. The treatment of this viral infection is also widely progressing. Among many agents, recombinant interferon alpha therapy is generally accepted as an effective single agent. To evaluate the efficacy of interferon and to observe the changes of serum aminotransferase (ALT), antibody to hepatitis C virus (anti-HCV) and HCV ribonucleic acid (HCV-RNA), we treated 10 patients with chronic type C hepatitis for 6 months. METHODS: Patients were randomly divided into 2 groups: 5 patients in group A received interferon and the other 5 in group B received no therapy. Interferon was administered at a dose of 3 million units (MU) daily for the first month and thrice weekly for the following 5 months, and followed up for 2 years. RESULTS: In group A, serum ALT returned to normal in 4: 3, starting at the first month and one at the 3rd month of therapy and maintained normal throughout the follow-up period. In contrast, serum ALT level persistently fluctuated in 4 patients in group B. In one patient, serum ALT returned to normal one and a half years later. Regardless of therapy, serum anti-HCV titer remained unchanged in all patients. However, HCV-RNA, using polymerized chain reaction (PCR), became undetetable in all responded patients and in one untreated patient whose serum ALT returned to normal spontaneously. CONCLUSION: This study suggested that interferon alpha therapy in patients with chronic type C hepatitis may be clinically effective. Our study also indicated that the detection of HCV-RNA by PCR is useful to predict the prognosis of chronic type C hepatitis. Korean Association of Internal Medicine 1992-01 /pmc/articles/PMC4532103/ /pubmed/1282364 http://dx.doi.org/10.3904/kjim.1992.7.1.13 Text en Copyright © 1992 The Korean Association of Internal Medicine This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Articles Cho, Ho Jun Dong, Seok Ho Lee, Myung Suk Kim, Hak Yang Park, Choong Kee Yoo, Jae Young Polito, Allan Quan, Stella Han, Jang Hyun Interferon Alpha Therapy in Patients with Chronic Type C Hepatitis: Changes of Serum ALT, Anti-HCV & HCV-RNA |
title | Interferon Alpha Therapy in Patients with Chronic Type C Hepatitis: Changes of Serum ALT, Anti-HCV & HCV-RNA |
title_full | Interferon Alpha Therapy in Patients with Chronic Type C Hepatitis: Changes of Serum ALT, Anti-HCV & HCV-RNA |
title_fullStr | Interferon Alpha Therapy in Patients with Chronic Type C Hepatitis: Changes of Serum ALT, Anti-HCV & HCV-RNA |
title_full_unstemmed | Interferon Alpha Therapy in Patients with Chronic Type C Hepatitis: Changes of Serum ALT, Anti-HCV & HCV-RNA |
title_short | Interferon Alpha Therapy in Patients with Chronic Type C Hepatitis: Changes of Serum ALT, Anti-HCV & HCV-RNA |
title_sort | interferon alpha therapy in patients with chronic type c hepatitis: changes of serum alt, anti-hcv & hcv-rna |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4532103/ https://www.ncbi.nlm.nih.gov/pubmed/1282364 http://dx.doi.org/10.3904/kjim.1992.7.1.13 |
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