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Influence of Amineptine on Changes of Blood Pressure Evoked by Norepinephrine and Dopamine
The influence of amineptine, an antidepressant currently employed having mainly selective dopaminergic neurochemical activity, on the pressor responses evoked by norepinephrine (NE) and dopamine (DA) was studied in anesthetized whole rats. Amineptine at doses of 0.5, 1.5, and 5.0 mg/kg/30 min infuse...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Association of Internal Medicine
1991
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4532118/ https://www.ncbi.nlm.nih.gov/pubmed/1807368 http://dx.doi.org/10.3904/kjim.1991.6.2.69 |
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author | Lim, Dong-Yoon Lee, Kwang-Jae Kim, Sang-Hoon Kim, Bong-Han Lee, Jon-Jin Lee, Eun-Hwa Chang, Kyoung-Sig Hong, Soon-Pyo |
author_facet | Lim, Dong-Yoon Lee, Kwang-Jae Kim, Sang-Hoon Kim, Bong-Han Lee, Jon-Jin Lee, Eun-Hwa Chang, Kyoung-Sig Hong, Soon-Pyo |
author_sort | Lim, Dong-Yoon |
collection | PubMed |
description | The influence of amineptine, an antidepressant currently employed having mainly selective dopaminergic neurochemical activity, on the pressor responses evoked by norepinephrine (NE) and dopamine (DA) was studied in anesthetized whole rats. Amineptine at doses of 0.5, 1.5, and 5.0 mg/kg/30 min infused into the femoral vein of the rat caused a dose-related inhibition of the pressor responses of NE and DA. The hypertensive responses of NE and DA augmented by pretreatment with reserpine, a catecholamine depletor, were also clearly depressed following the infusion of amineptine with a rate of 1.5 mg/kg/30 min. Furthermore, the pressor responses of NE and DA potentiated by pretreatment with debrisoquin, a sympathetic neuron blocker, were markedly diminished after pretreatment with the infusion of amineptine at the above same rate (1.5 mg/kg/30 min). These experimental results demonstrate that amineptine causes an inhibitory effect on the pressor responses evoked by NE and DA. It is thought that the amineptine effect may be due to the blockade of the peripheral adrenergic alpha-receptors in addition to the previously described uptake inhibition of dopamine. |
format | Online Article Text |
id | pubmed-4532118 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1991 |
publisher | Korean Association of Internal Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-45321182015-10-02 Influence of Amineptine on Changes of Blood Pressure Evoked by Norepinephrine and Dopamine Lim, Dong-Yoon Lee, Kwang-Jae Kim, Sang-Hoon Kim, Bong-Han Lee, Jon-Jin Lee, Eun-Hwa Chang, Kyoung-Sig Hong, Soon-Pyo Korean J Intern Med Original Article The influence of amineptine, an antidepressant currently employed having mainly selective dopaminergic neurochemical activity, on the pressor responses evoked by norepinephrine (NE) and dopamine (DA) was studied in anesthetized whole rats. Amineptine at doses of 0.5, 1.5, and 5.0 mg/kg/30 min infused into the femoral vein of the rat caused a dose-related inhibition of the pressor responses of NE and DA. The hypertensive responses of NE and DA augmented by pretreatment with reserpine, a catecholamine depletor, were also clearly depressed following the infusion of amineptine with a rate of 1.5 mg/kg/30 min. Furthermore, the pressor responses of NE and DA potentiated by pretreatment with debrisoquin, a sympathetic neuron blocker, were markedly diminished after pretreatment with the infusion of amineptine at the above same rate (1.5 mg/kg/30 min). These experimental results demonstrate that amineptine causes an inhibitory effect on the pressor responses evoked by NE and DA. It is thought that the amineptine effect may be due to the blockade of the peripheral adrenergic alpha-receptors in addition to the previously described uptake inhibition of dopamine. Korean Association of Internal Medicine 1991-07 /pmc/articles/PMC4532118/ /pubmed/1807368 http://dx.doi.org/10.3904/kjim.1991.6.2.69 Text en Copyright © 1991 The Korean Association of Internal Medicine This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Lim, Dong-Yoon Lee, Kwang-Jae Kim, Sang-Hoon Kim, Bong-Han Lee, Jon-Jin Lee, Eun-Hwa Chang, Kyoung-Sig Hong, Soon-Pyo Influence of Amineptine on Changes of Blood Pressure Evoked by Norepinephrine and Dopamine |
title | Influence of Amineptine on Changes of Blood Pressure Evoked by Norepinephrine and Dopamine |
title_full | Influence of Amineptine on Changes of Blood Pressure Evoked by Norepinephrine and Dopamine |
title_fullStr | Influence of Amineptine on Changes of Blood Pressure Evoked by Norepinephrine and Dopamine |
title_full_unstemmed | Influence of Amineptine on Changes of Blood Pressure Evoked by Norepinephrine and Dopamine |
title_short | Influence of Amineptine on Changes of Blood Pressure Evoked by Norepinephrine and Dopamine |
title_sort | influence of amineptine on changes of blood pressure evoked by norepinephrine and dopamine |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4532118/ https://www.ncbi.nlm.nih.gov/pubmed/1807368 http://dx.doi.org/10.3904/kjim.1991.6.2.69 |
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