Cargando…
A Retrospective Study on Radiotherapy and Radiochemotherapy in Esophageal Cancer
One hundred nineteen patients with inoperable esophageal cancer who had been treated with radiotherapy and/or chemotherapy from Jan. 1982 to Dec. 1986 at the Korea Cancer Center Hospital were retrospectively analyzed. Of 119 patients, 111 were male, and eight were female. Ten (8%) had a lesion in th...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Association of Internal Medicine
1988
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4532138/ https://www.ncbi.nlm.nih.gov/pubmed/3153794 http://dx.doi.org/10.3904/kjim.1988.3.1.58 |
_version_ | 1782385186078457856 |
---|---|
author | Kim, Chang-Min Hong, Weon-Seon Lee, Jhin-Oh Kang, Tae-Woong Kim, Yong-Hyon Cho, Chul-Gu Koh, Kyoung-Hwan Yoo, Seong-Yul |
author_facet | Kim, Chang-Min Hong, Weon-Seon Lee, Jhin-Oh Kang, Tae-Woong Kim, Yong-Hyon Cho, Chul-Gu Koh, Kyoung-Hwan Yoo, Seong-Yul |
author_sort | Kim, Chang-Min |
collection | PubMed |
description | One hundred nineteen patients with inoperable esophageal cancer who had been treated with radiotherapy and/or chemotherapy from Jan. 1982 to Dec. 1986 at the Korea Cancer Center Hospital were retrospectively analyzed. Of 119 patients, 111 were male, and eight were female. Ten (8%) had a lesion in the cervical esophagus; 71 (60%), in the upper and midthoracic esophagus; and 38 (32%), in the lower esophagus. One hundred ten (92%) patients had squamous cell carcinoma, and nine (8%) had adenocarcinoma. In 40 patients receiving radiotherapy alone, the response rate was 50% (complete response, 10%; partial response, 40%) with a median survival of 9 months. The 1-, 2-, and 3-year survival rates were 35%, 10%, and 5%, respectively. In 36 patients receiving radiochemotherapy, the response rate was 61% (complete response. 20%; partial response, 41%) with a median survival of 15 months. The 1-, 2-, and 3-year survival rates were 45%, 31%, and 12%, respectively. Six patients who had received chemotherapy alone had no objective response and died within one year. None of the 37 patients who had not received a specific treatment for underlying cancer survived two years. T1 stage, a lesion in the cervical esophagus, and good performance status (0–2) were considered to be favorable prognostic factors. There was no significant difference in the response rate and the actuarial survival between the radiotherapy and radiochemotherapy groups. These results suggest that both radiotherapy and radiochemotherapy are effective treatment modalities for inoperable esophageal cancer. |
format | Online Article Text |
id | pubmed-4532138 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1988 |
publisher | Korean Association of Internal Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-45321382015-10-02 A Retrospective Study on Radiotherapy and Radiochemotherapy in Esophageal Cancer Kim, Chang-Min Hong, Weon-Seon Lee, Jhin-Oh Kang, Tae-Woong Kim, Yong-Hyon Cho, Chul-Gu Koh, Kyoung-Hwan Yoo, Seong-Yul Korean J Intern Med Original Article One hundred nineteen patients with inoperable esophageal cancer who had been treated with radiotherapy and/or chemotherapy from Jan. 1982 to Dec. 1986 at the Korea Cancer Center Hospital were retrospectively analyzed. Of 119 patients, 111 were male, and eight were female. Ten (8%) had a lesion in the cervical esophagus; 71 (60%), in the upper and midthoracic esophagus; and 38 (32%), in the lower esophagus. One hundred ten (92%) patients had squamous cell carcinoma, and nine (8%) had adenocarcinoma. In 40 patients receiving radiotherapy alone, the response rate was 50% (complete response, 10%; partial response, 40%) with a median survival of 9 months. The 1-, 2-, and 3-year survival rates were 35%, 10%, and 5%, respectively. In 36 patients receiving radiochemotherapy, the response rate was 61% (complete response. 20%; partial response, 41%) with a median survival of 15 months. The 1-, 2-, and 3-year survival rates were 45%, 31%, and 12%, respectively. Six patients who had received chemotherapy alone had no objective response and died within one year. None of the 37 patients who had not received a specific treatment for underlying cancer survived two years. T1 stage, a lesion in the cervical esophagus, and good performance status (0–2) were considered to be favorable prognostic factors. There was no significant difference in the response rate and the actuarial survival between the radiotherapy and radiochemotherapy groups. These results suggest that both radiotherapy and radiochemotherapy are effective treatment modalities for inoperable esophageal cancer. Korean Association of Internal Medicine 1988-01 /pmc/articles/PMC4532138/ /pubmed/3153794 http://dx.doi.org/10.3904/kjim.1988.3.1.58 Text en Copyright © 1988 The Korean Association of Internal Medicine This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Kim, Chang-Min Hong, Weon-Seon Lee, Jhin-Oh Kang, Tae-Woong Kim, Yong-Hyon Cho, Chul-Gu Koh, Kyoung-Hwan Yoo, Seong-Yul A Retrospective Study on Radiotherapy and Radiochemotherapy in Esophageal Cancer |
title | A Retrospective Study on Radiotherapy and Radiochemotherapy in Esophageal Cancer |
title_full | A Retrospective Study on Radiotherapy and Radiochemotherapy in Esophageal Cancer |
title_fullStr | A Retrospective Study on Radiotherapy and Radiochemotherapy in Esophageal Cancer |
title_full_unstemmed | A Retrospective Study on Radiotherapy and Radiochemotherapy in Esophageal Cancer |
title_short | A Retrospective Study on Radiotherapy and Radiochemotherapy in Esophageal Cancer |
title_sort | retrospective study on radiotherapy and radiochemotherapy in esophageal cancer |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4532138/ https://www.ncbi.nlm.nih.gov/pubmed/3153794 http://dx.doi.org/10.3904/kjim.1988.3.1.58 |
work_keys_str_mv | AT kimchangmin aretrospectivestudyonradiotherapyandradiochemotherapyinesophagealcancer AT hongweonseon aretrospectivestudyonradiotherapyandradiochemotherapyinesophagealcancer AT leejhinoh aretrospectivestudyonradiotherapyandradiochemotherapyinesophagealcancer AT kangtaewoong aretrospectivestudyonradiotherapyandradiochemotherapyinesophagealcancer AT kimyonghyon aretrospectivestudyonradiotherapyandradiochemotherapyinesophagealcancer AT chochulgu aretrospectivestudyonradiotherapyandradiochemotherapyinesophagealcancer AT kohkyounghwan aretrospectivestudyonradiotherapyandradiochemotherapyinesophagealcancer AT yooseongyul aretrospectivestudyonradiotherapyandradiochemotherapyinesophagealcancer AT kimchangmin retrospectivestudyonradiotherapyandradiochemotherapyinesophagealcancer AT hongweonseon retrospectivestudyonradiotherapyandradiochemotherapyinesophagealcancer AT leejhinoh retrospectivestudyonradiotherapyandradiochemotherapyinesophagealcancer AT kangtaewoong retrospectivestudyonradiotherapyandradiochemotherapyinesophagealcancer AT kimyonghyon retrospectivestudyonradiotherapyandradiochemotherapyinesophagealcancer AT chochulgu retrospectivestudyonradiotherapyandradiochemotherapyinesophagealcancer AT kohkyounghwan retrospectivestudyonradiotherapyandradiochemotherapyinesophagealcancer AT yooseongyul retrospectivestudyonradiotherapyandradiochemotherapyinesophagealcancer |