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A Retrospective Study on Radiotherapy and Radiochemotherapy in Esophageal Cancer

One hundred nineteen patients with inoperable esophageal cancer who had been treated with radiotherapy and/or chemotherapy from Jan. 1982 to Dec. 1986 at the Korea Cancer Center Hospital were retrospectively analyzed. Of 119 patients, 111 were male, and eight were female. Ten (8%) had a lesion in th...

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Autores principales: Kim, Chang-Min, Hong, Weon-Seon, Lee, Jhin-Oh, Kang, Tae-Woong, Kim, Yong-Hyon, Cho, Chul-Gu, Koh, Kyoung-Hwan, Yoo, Seong-Yul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Association of Internal Medicine 1988
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4532138/
https://www.ncbi.nlm.nih.gov/pubmed/3153794
http://dx.doi.org/10.3904/kjim.1988.3.1.58
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author Kim, Chang-Min
Hong, Weon-Seon
Lee, Jhin-Oh
Kang, Tae-Woong
Kim, Yong-Hyon
Cho, Chul-Gu
Koh, Kyoung-Hwan
Yoo, Seong-Yul
author_facet Kim, Chang-Min
Hong, Weon-Seon
Lee, Jhin-Oh
Kang, Tae-Woong
Kim, Yong-Hyon
Cho, Chul-Gu
Koh, Kyoung-Hwan
Yoo, Seong-Yul
author_sort Kim, Chang-Min
collection PubMed
description One hundred nineteen patients with inoperable esophageal cancer who had been treated with radiotherapy and/or chemotherapy from Jan. 1982 to Dec. 1986 at the Korea Cancer Center Hospital were retrospectively analyzed. Of 119 patients, 111 were male, and eight were female. Ten (8%) had a lesion in the cervical esophagus; 71 (60%), in the upper and midthoracic esophagus; and 38 (32%), in the lower esophagus. One hundred ten (92%) patients had squamous cell carcinoma, and nine (8%) had adenocarcinoma. In 40 patients receiving radiotherapy alone, the response rate was 50% (complete response, 10%; partial response, 40%) with a median survival of 9 months. The 1-, 2-, and 3-year survival rates were 35%, 10%, and 5%, respectively. In 36 patients receiving radiochemotherapy, the response rate was 61% (complete response. 20%; partial response, 41%) with a median survival of 15 months. The 1-, 2-, and 3-year survival rates were 45%, 31%, and 12%, respectively. Six patients who had received chemotherapy alone had no objective response and died within one year. None of the 37 patients who had not received a specific treatment for underlying cancer survived two years. T1 stage, a lesion in the cervical esophagus, and good performance status (0–2) were considered to be favorable prognostic factors. There was no significant difference in the response rate and the actuarial survival between the radiotherapy and radiochemotherapy groups. These results suggest that both radiotherapy and radiochemotherapy are effective treatment modalities for inoperable esophageal cancer.
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spelling pubmed-45321382015-10-02 A Retrospective Study on Radiotherapy and Radiochemotherapy in Esophageal Cancer Kim, Chang-Min Hong, Weon-Seon Lee, Jhin-Oh Kang, Tae-Woong Kim, Yong-Hyon Cho, Chul-Gu Koh, Kyoung-Hwan Yoo, Seong-Yul Korean J Intern Med Original Article One hundred nineteen patients with inoperable esophageal cancer who had been treated with radiotherapy and/or chemotherapy from Jan. 1982 to Dec. 1986 at the Korea Cancer Center Hospital were retrospectively analyzed. Of 119 patients, 111 were male, and eight were female. Ten (8%) had a lesion in the cervical esophagus; 71 (60%), in the upper and midthoracic esophagus; and 38 (32%), in the lower esophagus. One hundred ten (92%) patients had squamous cell carcinoma, and nine (8%) had adenocarcinoma. In 40 patients receiving radiotherapy alone, the response rate was 50% (complete response, 10%; partial response, 40%) with a median survival of 9 months. The 1-, 2-, and 3-year survival rates were 35%, 10%, and 5%, respectively. In 36 patients receiving radiochemotherapy, the response rate was 61% (complete response. 20%; partial response, 41%) with a median survival of 15 months. The 1-, 2-, and 3-year survival rates were 45%, 31%, and 12%, respectively. Six patients who had received chemotherapy alone had no objective response and died within one year. None of the 37 patients who had not received a specific treatment for underlying cancer survived two years. T1 stage, a lesion in the cervical esophagus, and good performance status (0–2) were considered to be favorable prognostic factors. There was no significant difference in the response rate and the actuarial survival between the radiotherapy and radiochemotherapy groups. These results suggest that both radiotherapy and radiochemotherapy are effective treatment modalities for inoperable esophageal cancer. Korean Association of Internal Medicine 1988-01 /pmc/articles/PMC4532138/ /pubmed/3153794 http://dx.doi.org/10.3904/kjim.1988.3.1.58 Text en Copyright © 1988 The Korean Association of Internal Medicine This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Kim, Chang-Min
Hong, Weon-Seon
Lee, Jhin-Oh
Kang, Tae-Woong
Kim, Yong-Hyon
Cho, Chul-Gu
Koh, Kyoung-Hwan
Yoo, Seong-Yul
A Retrospective Study on Radiotherapy and Radiochemotherapy in Esophageal Cancer
title A Retrospective Study on Radiotherapy and Radiochemotherapy in Esophageal Cancer
title_full A Retrospective Study on Radiotherapy and Radiochemotherapy in Esophageal Cancer
title_fullStr A Retrospective Study on Radiotherapy and Radiochemotherapy in Esophageal Cancer
title_full_unstemmed A Retrospective Study on Radiotherapy and Radiochemotherapy in Esophageal Cancer
title_short A Retrospective Study on Radiotherapy and Radiochemotherapy in Esophageal Cancer
title_sort retrospective study on radiotherapy and radiochemotherapy in esophageal cancer
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4532138/
https://www.ncbi.nlm.nih.gov/pubmed/3153794
http://dx.doi.org/10.3904/kjim.1988.3.1.58
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