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The impact of nocturnal disturbances on daily quality of life in patients with Parkinson’s disease

OBJECTIVES: The aims of this study were to explore nocturnal disturbances in patients with Parkinson’s disease (PD) and to assess their impact on quality of life (QoL). METHODS: A total of 211 patients with PD were recruited for this study, and each participant was evaluated using the mini-mental st...

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Autores principales: Yu, Rwei-Ling, Tan, Chun-Hsiang, Wu, Ruey-Meei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4532217/
https://www.ncbi.nlm.nih.gov/pubmed/26273203
http://dx.doi.org/10.2147/NDT.S85483
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author Yu, Rwei-Ling
Tan, Chun-Hsiang
Wu, Ruey-Meei
author_facet Yu, Rwei-Ling
Tan, Chun-Hsiang
Wu, Ruey-Meei
author_sort Yu, Rwei-Ling
collection PubMed
description OBJECTIVES: The aims of this study were to explore nocturnal disturbances in patients with Parkinson’s disease (PD) and to assess their impact on quality of life (QoL). METHODS: A total of 211 patients with PD were recruited for this study, and each participant was evaluated using the mini-mental state examination, PD sleep scale – second version (PDSS-2), pittsburgh sleep quality index (PSQI), PD QoL questionnaire (PDQ), Epworth sleepiness scale, Hoehn and Yahr (H&Y) staging, and unified Parkinson’s disease rating scale (UPDRS). Multiple regression analyses were performed to determine the contribution of the predictive variables on QoL. RESULTS: There were 56.4% males (mean age: 64.08 years; disease duration: 6.02 years; H&Y stage: 2.25; and UPDRS: 33.01) in this study. Our patients’ actual sleep time was 5.96±1.16 hours and the average sleep efficiency was 82.93%±12.79%. Up to 64.4% of patients were classified as “poor” sleepers and 23.8% suffered from daytime sleepiness. The final stepwise regression model revealed that UPDRS parts I and II, the sleep disturbance and daytime dysfunction components of the PSQI, the PD symptoms at night subscale of the PDSS-2, and the levodopa equivalent dose were significant predictors of the PDQ score (R(2)=53, F(7,165)=28.746; P<0.001). CONCLUSION: Most of the PD patients have sleep problems, and nearly one-quarter of them have abnormal daytime somnolence. The nocturnal disturbances were found to result in worse QoL in PD patients. Ethnicity-specific effects of susceptibility to sleep disturbances were discussed, and these results also highlighted the direction for further studies to explore when examining effective management programs toward these disturbances.
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spelling pubmed-45322172015-08-13 The impact of nocturnal disturbances on daily quality of life in patients with Parkinson’s disease Yu, Rwei-Ling Tan, Chun-Hsiang Wu, Ruey-Meei Neuropsychiatr Dis Treat Original Research OBJECTIVES: The aims of this study were to explore nocturnal disturbances in patients with Parkinson’s disease (PD) and to assess their impact on quality of life (QoL). METHODS: A total of 211 patients with PD were recruited for this study, and each participant was evaluated using the mini-mental state examination, PD sleep scale – second version (PDSS-2), pittsburgh sleep quality index (PSQI), PD QoL questionnaire (PDQ), Epworth sleepiness scale, Hoehn and Yahr (H&Y) staging, and unified Parkinson’s disease rating scale (UPDRS). Multiple regression analyses were performed to determine the contribution of the predictive variables on QoL. RESULTS: There were 56.4% males (mean age: 64.08 years; disease duration: 6.02 years; H&Y stage: 2.25; and UPDRS: 33.01) in this study. Our patients’ actual sleep time was 5.96±1.16 hours and the average sleep efficiency was 82.93%±12.79%. Up to 64.4% of patients were classified as “poor” sleepers and 23.8% suffered from daytime sleepiness. The final stepwise regression model revealed that UPDRS parts I and II, the sleep disturbance and daytime dysfunction components of the PSQI, the PD symptoms at night subscale of the PDSS-2, and the levodopa equivalent dose were significant predictors of the PDQ score (R(2)=53, F(7,165)=28.746; P<0.001). CONCLUSION: Most of the PD patients have sleep problems, and nearly one-quarter of them have abnormal daytime somnolence. The nocturnal disturbances were found to result in worse QoL in PD patients. Ethnicity-specific effects of susceptibility to sleep disturbances were discussed, and these results also highlighted the direction for further studies to explore when examining effective management programs toward these disturbances. Dove Medical Press 2015-08-06 /pmc/articles/PMC4532217/ /pubmed/26273203 http://dx.doi.org/10.2147/NDT.S85483 Text en © 2015 Yu et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Yu, Rwei-Ling
Tan, Chun-Hsiang
Wu, Ruey-Meei
The impact of nocturnal disturbances on daily quality of life in patients with Parkinson’s disease
title The impact of nocturnal disturbances on daily quality of life in patients with Parkinson’s disease
title_full The impact of nocturnal disturbances on daily quality of life in patients with Parkinson’s disease
title_fullStr The impact of nocturnal disturbances on daily quality of life in patients with Parkinson’s disease
title_full_unstemmed The impact of nocturnal disturbances on daily quality of life in patients with Parkinson’s disease
title_short The impact of nocturnal disturbances on daily quality of life in patients with Parkinson’s disease
title_sort impact of nocturnal disturbances on daily quality of life in patients with parkinson’s disease
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4532217/
https://www.ncbi.nlm.nih.gov/pubmed/26273203
http://dx.doi.org/10.2147/NDT.S85483
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