Failure of a Single Varicella Vaccination to Protect Children With Cancer From Life-Threatening Breakthrough Varicella

We report 2 children with life-threatening breakthrough varicella. Both had received 1 varicella vaccination before onset of cancer. Despite treatment with intravenous acyclovir, 1 child died of disseminated varicella. Because similar fatal cases have been reported, high-risk immunocompromised child...

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Detalles Bibliográficos
Autores principales: Kelley, James, Tristram, Debra, Yamada, Masaki, Grose, Charles
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Williams & Wilkins 2015
Materias:
Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4532322/
https://www.ncbi.nlm.nih.gov/pubmed/25955833
http://dx.doi.org/10.1097/INF.0000000000000737
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author Kelley, James
Tristram, Debra
Yamada, Masaki
Grose, Charles
author_facet Kelley, James
Tristram, Debra
Yamada, Masaki
Grose, Charles
author_sort Kelley, James
collection PubMed
description We report 2 children with life-threatening breakthrough varicella. Both had received 1 varicella vaccination before onset of cancer. Despite treatment with intravenous acyclovir, 1 child died of disseminated varicella. Because similar fatal cases have been reported, high-risk immunocompromised children with 1 varicella vaccination may warrant the same varicella prophylaxis as immunocompromised children who have never been vaccinated.
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spelling pubmed-45323222015-08-19 Failure of a Single Varicella Vaccination to Protect Children With Cancer From Life-Threatening Breakthrough Varicella Kelley, James Tristram, Debra Yamada, Masaki Grose, Charles Pediatr Infect Dis J Brief Reports We report 2 children with life-threatening breakthrough varicella. Both had received 1 varicella vaccination before onset of cancer. Despite treatment with intravenous acyclovir, 1 child died of disseminated varicella. Because similar fatal cases have been reported, high-risk immunocompromised children with 1 varicella vaccination may warrant the same varicella prophylaxis as immunocompromised children who have never been vaccinated. Williams & Wilkins 2015-09 2015-08-13 /pmc/articles/PMC4532322/ /pubmed/25955833 http://dx.doi.org/10.1097/INF.0000000000000737 Text en Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License, where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially.
spellingShingle Brief Reports
Kelley, James
Tristram, Debra
Yamada, Masaki
Grose, Charles
Failure of a Single Varicella Vaccination to Protect Children With Cancer From Life-Threatening Breakthrough Varicella
title Failure of a Single Varicella Vaccination to Protect Children With Cancer From Life-Threatening Breakthrough Varicella
title_full Failure of a Single Varicella Vaccination to Protect Children With Cancer From Life-Threatening Breakthrough Varicella
title_fullStr Failure of a Single Varicella Vaccination to Protect Children With Cancer From Life-Threatening Breakthrough Varicella
title_full_unstemmed Failure of a Single Varicella Vaccination to Protect Children With Cancer From Life-Threatening Breakthrough Varicella
title_short Failure of a Single Varicella Vaccination to Protect Children With Cancer From Life-Threatening Breakthrough Varicella
title_sort failure of a single varicella vaccination to protect children with cancer from life-threatening breakthrough varicella
topic Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4532322/
https://www.ncbi.nlm.nih.gov/pubmed/25955833
http://dx.doi.org/10.1097/INF.0000000000000737
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