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Emerging treatment options to improve cardiovascular outcomes in patients with acute coronary syndrome: focus on losmapimod
Each year, despite optimal use of recommended acute and secondary prevention therapies, 4%–5% of patients with acute coronary syndrome (ACS) experience relapse of ACS or other cardiovascular events including stroke, heart failure, or sudden cardiac death after the index ACS. The sudden atherosclerot...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4532348/ https://www.ncbi.nlm.nih.gov/pubmed/26273189 http://dx.doi.org/10.2147/DDDT.S69546 |
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author | Kragholm, Kristian Newby, Laura Kristin Melloni, Chiara |
author_facet | Kragholm, Kristian Newby, Laura Kristin Melloni, Chiara |
author_sort | Kragholm, Kristian |
collection | PubMed |
description | Each year, despite optimal use of recommended acute and secondary prevention therapies, 4%–5% of patients with acute coronary syndrome (ACS) experience relapse of ACS or other cardiovascular events including stroke, heart failure, or sudden cardiac death after the index ACS. The sudden atherosclerotic plaque rupture leading to an ACS event is often accompanied by inflammation, which is thought to be a key pathogenic pathway to these excess cardiovascular events. Losmapimod is a novel, oral p38 mitogen-activated protein kinase (MAPK) inhibitor that targets MAPKs activated in macrophages, myocardium, and endothelial cells that occur as a part of global coronary vascular inflammation following plaque rupture. This review aims to 1) discuss the pathophysiological pathways through which p38 MAPKs may play key roles in initiation and progression of inflammatory disease and how losmapimod is thought to counteract these p38 MAPKs, and 2) to describe the efficacy and safety data for losmapimod obtained from preclinical studies and randomized controlled trials that support the hypothesis that it has promise as a treatment for patients with ACS. |
format | Online Article Text |
id | pubmed-4532348 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-45323482015-08-13 Emerging treatment options to improve cardiovascular outcomes in patients with acute coronary syndrome: focus on losmapimod Kragholm, Kristian Newby, Laura Kristin Melloni, Chiara Drug Des Devel Ther Review Each year, despite optimal use of recommended acute and secondary prevention therapies, 4%–5% of patients with acute coronary syndrome (ACS) experience relapse of ACS or other cardiovascular events including stroke, heart failure, or sudden cardiac death after the index ACS. The sudden atherosclerotic plaque rupture leading to an ACS event is often accompanied by inflammation, which is thought to be a key pathogenic pathway to these excess cardiovascular events. Losmapimod is a novel, oral p38 mitogen-activated protein kinase (MAPK) inhibitor that targets MAPKs activated in macrophages, myocardium, and endothelial cells that occur as a part of global coronary vascular inflammation following plaque rupture. This review aims to 1) discuss the pathophysiological pathways through which p38 MAPKs may play key roles in initiation and progression of inflammatory disease and how losmapimod is thought to counteract these p38 MAPKs, and 2) to describe the efficacy and safety data for losmapimod obtained from preclinical studies and randomized controlled trials that support the hypothesis that it has promise as a treatment for patients with ACS. Dove Medical Press 2015-08-05 /pmc/articles/PMC4532348/ /pubmed/26273189 http://dx.doi.org/10.2147/DDDT.S69546 Text en © 2015 Kragholm et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Review Kragholm, Kristian Newby, Laura Kristin Melloni, Chiara Emerging treatment options to improve cardiovascular outcomes in patients with acute coronary syndrome: focus on losmapimod |
title | Emerging treatment options to improve cardiovascular outcomes in patients with acute coronary syndrome: focus on losmapimod |
title_full | Emerging treatment options to improve cardiovascular outcomes in patients with acute coronary syndrome: focus on losmapimod |
title_fullStr | Emerging treatment options to improve cardiovascular outcomes in patients with acute coronary syndrome: focus on losmapimod |
title_full_unstemmed | Emerging treatment options to improve cardiovascular outcomes in patients with acute coronary syndrome: focus on losmapimod |
title_short | Emerging treatment options to improve cardiovascular outcomes in patients with acute coronary syndrome: focus on losmapimod |
title_sort | emerging treatment options to improve cardiovascular outcomes in patients with acute coronary syndrome: focus on losmapimod |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4532348/ https://www.ncbi.nlm.nih.gov/pubmed/26273189 http://dx.doi.org/10.2147/DDDT.S69546 |
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