Chronic Insulin Exposure Induces ER Stress and Lipid Body Accumulation in Mast Cells at the Expense of Their Secretory Degranulation Response

Lipid bodies (LB) are reservoirs of precursors to inflammatory lipid mediators in immunocytes, including mast cells. LB numbers are dynamic, increasing dramatically under conditions of immunological challenge. We have previously shown in vitro that insulin-influenced lipogenic pathways induce LB bio...

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Detalles Bibliográficos
Autores principales: Greineisen, William E., Maaetoft-Udsen, Kristina, Speck, Mark, Balajadia, Januaria, Shimoda, Lori M. N., Sung, Carl, Turner, Helen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4532411/
https://www.ncbi.nlm.nih.gov/pubmed/26263026
http://dx.doi.org/10.1371/journal.pone.0130198

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