Cargando…

Prognostic Value of Yes-Associated Protein 1 (YAP1) in Various Cancers: A Meta-Analysis

BACKGROUND: Yes-associated protein 1 (YAP1) is an effector of Hippo pathway, which is critical for regulating organ size, cell proliferation and tumor growth in mammals. Many previous studies have explored the relationship between YAP1 and various types of cancer. However, these studies were limited...

Descripción completa

Detalles Bibliográficos
Autores principales: Sun, Zhenqiang, Xu, Ruiwei, Li, Xiayu, Ren, Weiguo, Ou, Chunlin, Wang, Qisan, Zhang, Han, Zhang, Xuemei, Ma, Jian, Wang, Haijiang, Li, Guiyuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4532485/
https://www.ncbi.nlm.nih.gov/pubmed/26263504
http://dx.doi.org/10.1371/journal.pone.0135119
_version_ 1782385228111675392
author Sun, Zhenqiang
Xu, Ruiwei
Li, Xiayu
Ren, Weiguo
Ou, Chunlin
Wang, Qisan
Zhang, Han
Zhang, Xuemei
Ma, Jian
Wang, Haijiang
Li, Guiyuan
author_facet Sun, Zhenqiang
Xu, Ruiwei
Li, Xiayu
Ren, Weiguo
Ou, Chunlin
Wang, Qisan
Zhang, Han
Zhang, Xuemei
Ma, Jian
Wang, Haijiang
Li, Guiyuan
author_sort Sun, Zhenqiang
collection PubMed
description BACKGROUND: Yes-associated protein 1 (YAP1) is an effector of Hippo pathway, which is critical for regulating organ size, cell proliferation and tumor growth in mammals. Many previous studies have explored the relationship between YAP1 and various types of cancer. However, these studies were limited by the small samples size and the findings were inconsistent among them. Therefore, a meta-analysis was conducted to assess the association between YAP1 and malignancies. METHODS: A systematic literature search was conducted for eligible studies in the PubMed, Corchane Library, Web of Knowledge, EMBASE and CBM disc databases from inception to August 1(st) 2014. After heterogeneity analysis, pooled harzad ratio (HR) with 95% confidence interval (95%CI) using both fixed and random effect models were estimated in STATA 10.0. Meta regression analysis, subgroup analysis and sensitivity analysis were performed to explore the potential sources of heterogeneity and to evaluate the robustness of the result. Publication bias was assessed by Egger’s test and funnel plot. RESULTS: A total of 21 unique articles from 2009 to 2014, comprising 2983 patients, were analyzed in the meta-analysis. The association of YAP1 expression and overall survival time (OS) was evaluated in 20 studies including 2067 patients. Positive YAP1 showed poorer OS (HR = 1.826; 95% CI = 1.465–2.275; p <0.002). For evaluating disease-free survival time (DFS), 10 studies with 1139 patients were analyzed. Positive YAP1 indicated worse DFS (HR = 2.114; 95%CI = 1.406–3.179; p <0.001). Subgroup analysis showed that both positive nuclear YAP1 (HR = 1.390, 95% CI: 0.810–2.400, p = 0.729) and up-regulation overall YAP1 (HR = 2.237, 95% CI: 1.548–3.232, p <0.001) had poorer OS for patients with malignancies. Similarly, both positive nuclear YAP1 (HR = 3.733, 95% CI: 1.469–9.483, p = 0.001) and up-regulation overall YAP1 (HR = 1.481, 95% CI: 1.163–1.886, p = 0.554) showed worse DFS. The patients with urogenital system cancer had the poorest OS (HR = 2.133, 95% CI: 1.549–2.937, p = 0.020). The patients with alimentary system cancer had the most significant impact on DFS (HR = 1.879, 95% CI: 1.537–2.297, p <0.001). CONCLUSION: Both overall and nuclear YAP1 overexpression are intimately associated with adverse OS and DFS in numerous cancers, suggesting that YAP1 may act as a potential therapeutic targets of these malignancies in the future.
format Online
Article
Text
id pubmed-4532485
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-45324852015-08-20 Prognostic Value of Yes-Associated Protein 1 (YAP1) in Various Cancers: A Meta-Analysis Sun, Zhenqiang Xu, Ruiwei Li, Xiayu Ren, Weiguo Ou, Chunlin Wang, Qisan Zhang, Han Zhang, Xuemei Ma, Jian Wang, Haijiang Li, Guiyuan PLoS One Research Article BACKGROUND: Yes-associated protein 1 (YAP1) is an effector of Hippo pathway, which is critical for regulating organ size, cell proliferation and tumor growth in mammals. Many previous studies have explored the relationship between YAP1 and various types of cancer. However, these studies were limited by the small samples size and the findings were inconsistent among them. Therefore, a meta-analysis was conducted to assess the association between YAP1 and malignancies. METHODS: A systematic literature search was conducted for eligible studies in the PubMed, Corchane Library, Web of Knowledge, EMBASE and CBM disc databases from inception to August 1(st) 2014. After heterogeneity analysis, pooled harzad ratio (HR) with 95% confidence interval (95%CI) using both fixed and random effect models were estimated in STATA 10.0. Meta regression analysis, subgroup analysis and sensitivity analysis were performed to explore the potential sources of heterogeneity and to evaluate the robustness of the result. Publication bias was assessed by Egger’s test and funnel plot. RESULTS: A total of 21 unique articles from 2009 to 2014, comprising 2983 patients, were analyzed in the meta-analysis. The association of YAP1 expression and overall survival time (OS) was evaluated in 20 studies including 2067 patients. Positive YAP1 showed poorer OS (HR = 1.826; 95% CI = 1.465–2.275; p <0.002). For evaluating disease-free survival time (DFS), 10 studies with 1139 patients were analyzed. Positive YAP1 indicated worse DFS (HR = 2.114; 95%CI = 1.406–3.179; p <0.001). Subgroup analysis showed that both positive nuclear YAP1 (HR = 1.390, 95% CI: 0.810–2.400, p = 0.729) and up-regulation overall YAP1 (HR = 2.237, 95% CI: 1.548–3.232, p <0.001) had poorer OS for patients with malignancies. Similarly, both positive nuclear YAP1 (HR = 3.733, 95% CI: 1.469–9.483, p = 0.001) and up-regulation overall YAP1 (HR = 1.481, 95% CI: 1.163–1.886, p = 0.554) showed worse DFS. The patients with urogenital system cancer had the poorest OS (HR = 2.133, 95% CI: 1.549–2.937, p = 0.020). The patients with alimentary system cancer had the most significant impact on DFS (HR = 1.879, 95% CI: 1.537–2.297, p <0.001). CONCLUSION: Both overall and nuclear YAP1 overexpression are intimately associated with adverse OS and DFS in numerous cancers, suggesting that YAP1 may act as a potential therapeutic targets of these malignancies in the future. Public Library of Science 2015-08-11 /pmc/articles/PMC4532485/ /pubmed/26263504 http://dx.doi.org/10.1371/journal.pone.0135119 Text en © 2015 Sun et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Sun, Zhenqiang
Xu, Ruiwei
Li, Xiayu
Ren, Weiguo
Ou, Chunlin
Wang, Qisan
Zhang, Han
Zhang, Xuemei
Ma, Jian
Wang, Haijiang
Li, Guiyuan
Prognostic Value of Yes-Associated Protein 1 (YAP1) in Various Cancers: A Meta-Analysis
title Prognostic Value of Yes-Associated Protein 1 (YAP1) in Various Cancers: A Meta-Analysis
title_full Prognostic Value of Yes-Associated Protein 1 (YAP1) in Various Cancers: A Meta-Analysis
title_fullStr Prognostic Value of Yes-Associated Protein 1 (YAP1) in Various Cancers: A Meta-Analysis
title_full_unstemmed Prognostic Value of Yes-Associated Protein 1 (YAP1) in Various Cancers: A Meta-Analysis
title_short Prognostic Value of Yes-Associated Protein 1 (YAP1) in Various Cancers: A Meta-Analysis
title_sort prognostic value of yes-associated protein 1 (yap1) in various cancers: a meta-analysis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4532485/
https://www.ncbi.nlm.nih.gov/pubmed/26263504
http://dx.doi.org/10.1371/journal.pone.0135119
work_keys_str_mv AT sunzhenqiang prognosticvalueofyesassociatedprotein1yap1invariouscancersametaanalysis
AT xuruiwei prognosticvalueofyesassociatedprotein1yap1invariouscancersametaanalysis
AT lixiayu prognosticvalueofyesassociatedprotein1yap1invariouscancersametaanalysis
AT renweiguo prognosticvalueofyesassociatedprotein1yap1invariouscancersametaanalysis
AT ouchunlin prognosticvalueofyesassociatedprotein1yap1invariouscancersametaanalysis
AT wangqisan prognosticvalueofyesassociatedprotein1yap1invariouscancersametaanalysis
AT zhanghan prognosticvalueofyesassociatedprotein1yap1invariouscancersametaanalysis
AT zhangxuemei prognosticvalueofyesassociatedprotein1yap1invariouscancersametaanalysis
AT majian prognosticvalueofyesassociatedprotein1yap1invariouscancersametaanalysis
AT wanghaijiang prognosticvalueofyesassociatedprotein1yap1invariouscancersametaanalysis
AT liguiyuan prognosticvalueofyesassociatedprotein1yap1invariouscancersametaanalysis