Lyso-Sulfatide Binds Factor Xa and Inhibits Thrombin Generation by the Prothrombinase Complex

Blood coagulation reactions are strongly influenced by phospholipids, but little is known about the influence of sphingolipids on coagulation mechanisms. Lysosulfatide (lyso-SF) (sulfogalactosyl sphingosine) prolonged factor Xa (fXa) 1-stage plasma clotting assays, showing it had robust anticoagulan...

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Detalles Bibliográficos
Autores principales: Yegneswaran, Subramanian, Banerjee, Yajnavalka, Fernández, José A., Deguchi, Hiroshi, Griffin, John H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4532512/
https://www.ncbi.nlm.nih.gov/pubmed/26263376
http://dx.doi.org/10.1371/journal.pone.0135025

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4532512/
https://www.ncbi.nlm.nih.gov/pubmed/26263376
http://dx.doi.org/10.1371/journal.pone.0135025

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