Epigenetic control of Foxp3 by SMYD3 H3K4 histone methyltransferase controls iTreg development and regulates pathogenic T cell responses during pulmonary viral infection

The generation of regulatory T (Treg) cells is driven by Foxp3 and is responsible for dampening inflammation and reducing autoimmunity. In this study the epigenetic regulation of iTreg cells was examined and identified a H3K4 histone methyltransferase, SMYD3, which regulates expression of Foxp3 by a...

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Detalles Bibliográficos
Autores principales: de Almeida Nagata, Denise E., Ting, Hung-An, Cavassani, Karen A., Schaller, Matthew A., Mukherjee, Sumanta, Ptaschinski, Catherine, Kunkel, Steven L., Lukacs, Nicholas W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4532649/
https://www.ncbi.nlm.nih.gov/pubmed/25669152
http://dx.doi.org/10.1038/mi.2015.4

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