ATG16L1 deficiency in macrophages drives clearance of Uropathogenic E. coli in an IL-1β dependent manner

Urinary Tract Infections (UTIs) are frequent, commonly recurrent, and costly. Deficiency in a key autophagy protein, ATG16L1, protects mice from infection with the predominant bacterial cause of UTIs, Uropathogenic E. coli (UPEC). Here, we report that loss of ATG16L1 in macrophages accounts for this...

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Detalles Bibliográficos
Autores principales: Symington, Jane W., Wang, Caihong, Twentyman, Joy, Boaitey, Nana Owusu, Schwendener, Reto, Núñez, Gabriel, Schilling, Joel D., Mysorekar, Indira U.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4532666/
https://www.ncbi.nlm.nih.gov/pubmed/25669147
http://dx.doi.org/10.1038/mi.2015.7

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