Baclofen-Induced Encephalopathy in End Stage Renal Disease

Baclofen is a highly used centrally acting GABA agonist that continues to be an effective therapy for spasticity and chronic hiccups. The renally dependent excretion determines the circulating concentrations and guides effective dosing to decrease adverse reactions. Caution should be considered in a...

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Detalles Bibliográficos
Autores principales: Meillier, Andrew, Heller, Cara, Patel, Shyam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4532946/
https://www.ncbi.nlm.nih.gov/pubmed/26294912
http://dx.doi.org/10.1155/2015/203936
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author Meillier, Andrew
Heller, Cara
Patel, Shyam
author_facet Meillier, Andrew
Heller, Cara
Patel, Shyam
author_sort Meillier, Andrew
collection PubMed
description Baclofen is a highly used centrally acting GABA agonist that continues to be an effective therapy for spasticity and chronic hiccups. The renally dependent excretion determines the circulating concentrations and guides effective dosing to decrease adverse reactions. Caution should be considered in administering baclofen to patients with decreased renal function. We present a patient with end stage renal disease on hemodialysis with recent baclofen ingestion who presented with toxic encephalopathy that was resolved with additional dialysis sessions.
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spelling pubmed-45329462015-08-20 Baclofen-Induced Encephalopathy in End Stage Renal Disease Meillier, Andrew Heller, Cara Patel, Shyam Case Rep Med Case Report Baclofen is a highly used centrally acting GABA agonist that continues to be an effective therapy for spasticity and chronic hiccups. The renally dependent excretion determines the circulating concentrations and guides effective dosing to decrease adverse reactions. Caution should be considered in administering baclofen to patients with decreased renal function. We present a patient with end stage renal disease on hemodialysis with recent baclofen ingestion who presented with toxic encephalopathy that was resolved with additional dialysis sessions. Hindawi Publishing Corporation 2015 2015-07-29 /pmc/articles/PMC4532946/ /pubmed/26294912 http://dx.doi.org/10.1155/2015/203936 Text en Copyright © 2015 Andrew Meillier et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Meillier, Andrew
Heller, Cara
Patel, Shyam
Baclofen-Induced Encephalopathy in End Stage Renal Disease
title Baclofen-Induced Encephalopathy in End Stage Renal Disease
title_full Baclofen-Induced Encephalopathy in End Stage Renal Disease
title_fullStr Baclofen-Induced Encephalopathy in End Stage Renal Disease
title_full_unstemmed Baclofen-Induced Encephalopathy in End Stage Renal Disease
title_short Baclofen-Induced Encephalopathy in End Stage Renal Disease
title_sort baclofen-induced encephalopathy in end stage renal disease
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4532946/
https://www.ncbi.nlm.nih.gov/pubmed/26294912
http://dx.doi.org/10.1155/2015/203936
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