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Hypothesis: Obesity Is Associated with a Lower Mutation Threshold in Colon Cancer
Neoplastic progression requires accumulation of several mutations (mutation threshold). We hypothesize that obesity raises the risk of microsatellite stable (MSS) colon cancer (CC) at least in part by decreasing the mutation threshold. Thus, we posit that obese patients require fewer mutations, part...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Ivyspring International Publisher
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4532979/ https://www.ncbi.nlm.nih.gov/pubmed/26284133 http://dx.doi.org/10.7150/jca.12352 |