Enhancer of zeste homolog 2 silencing inhibits tumor growth and lung metastasis in osteosarcoma

The enhancer of zeste homolog 2 (EZH2) methyltransferase is the catalytic subunit of polycomb repressive complex 2 (PRC2), which acts as a transcription repressor via the trimethylation of lysine 27 of histone 3 (H3K27me3). EZH2 has been recognised as an oncogene in several types of tumors; however,...

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Detalles Bibliográficos
Autores principales: Lv, Yang-Fan, Yan, Guang-Ning, Meng, Gang, Zhang, Xi, Guo, Qiao-Nan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4533017/
https://www.ncbi.nlm.nih.gov/pubmed/26265454
http://dx.doi.org/10.1038/srep12999

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4533017/
https://www.ncbi.nlm.nih.gov/pubmed/26265454
http://dx.doi.org/10.1038/srep12999

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