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Naive CD8(+) T-cell precursors display structured TCR repertoires and composite antigen-driven selection dynamics

Basic parameters of the naive antigen (Ag)-specific T-cell repertoire in humans remain poorly defined. Systematic characterization of this ‘ground state' immunity in comparison with memory will allow a better understanding of clonal selection during immune challenge. Here, we used high-definiti...

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Detalles Bibliográficos
Autores principales:	Neller, Michelle A, Ladell, Kristin, McLaren, James E, Matthews, Katherine K, Gostick, Emma, Pentier, Johanne M, Dolton, Garry, Schauenburg, Andrea JA, Koning, Dan, Fontaine Costa, Ana Isabel CA, Watkins, Thomas S, Venturi, Vanessa, Smith, Corey, Khanna, Rajiv, Miners, Kelly, Clement, Mathew, Wooldridge, Linda, Cole, David K, van Baarle, Debbie, Sewell, Andrew K, Burrows, Scott R, Price, David A, Miles, John J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4533101/ https://www.ncbi.nlm.nih.gov/pubmed/25801351 http://dx.doi.org/10.1038/icb.2015.17

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