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Crystal structure of R-spondin 2 in complex with the ectodomains of its receptors LGR5 and ZNRF3()
The four secreted R-spondin (Rspo1-4) proteins of vertebrates function as stem cell growth factors and potentiate canonical Wnt signalling. Rspo proteins act by cross-linking members of two cell surface receptor families, complexing the stem cell markers LGR4-6 with the Frizzled-specific E3 ubiquiti...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Academic Press
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4533229/ https://www.ncbi.nlm.nih.gov/pubmed/26123262 http://dx.doi.org/10.1016/j.jsb.2015.05.008 |