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Pathology and Molecular Genetics of Meningioma: Recent Advances

Meningiomas are the most common intracranial primary neoplasm in adults. Although the spectrum of clinical and molecular genetic issues regarding meningiomas remains undefined, novel genetic alterations that are associated with tumor morphology, malignancy, or location have recently been discovered....

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Detalles Bibliográficos
Autor principal: SHIBUYA, Makoto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japan Neurosurgical Society 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4533397/
https://www.ncbi.nlm.nih.gov/pubmed/25744347
http://dx.doi.org/10.2176/nmc.ra.2014-0233
Descripción
Sumario:Meningiomas are the most common intracranial primary neoplasm in adults. Although the spectrum of clinical and molecular genetic issues regarding meningiomas remains undefined, novel genetic alterations that are associated with tumor morphology, malignancy, or location have recently been discovered. This review focuses on recent advances in understanding of the heterogenous pathology of meningiomas, particularly on associations between the clinical, histological, etiological, epidemiological, and molecular genetical aspects of the neoplasm.