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The Changes of c-Fos Expression by Motor Cortex Stimulation in the Deafferentation Pain Model

The effect of motor cortex stimulation (MCS) therapy for deafferentation pain was evaluated based on c-Fos, a known pain marker. Nineteen mature cats weighing 1.5–3.5 kg were used. Cats were divided into three groups: a deafferentation pain group in which the left trigeminal ganglion was destroyed,...

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Autores principales: KUDO, Kanae, TAKAHASHI, Toshio, SUZUKI, Shigeharu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japan Neurosurgical Society 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4533460/
https://www.ncbi.nlm.nih.gov/pubmed/24965534
http://dx.doi.org/10.2176/nmc.oa.2013-0321
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author KUDO, Kanae
TAKAHASHI, Toshio
SUZUKI, Shigeharu
author_facet KUDO, Kanae
TAKAHASHI, Toshio
SUZUKI, Shigeharu
author_sort KUDO, Kanae
collection PubMed
description The effect of motor cortex stimulation (MCS) therapy for deafferentation pain was evaluated based on c-Fos, a known pain marker. Nineteen mature cats weighing 1.5–3.5 kg were used. Cats were divided into three groups: a deafferentation pain group in which the left trigeminal ganglion was destroyed, an MCS group in which MCS was used following destruction of the trigeminal ganglion, and a control group. Sites and levels of c-Fos expression were examined immunohistochemically. The percentage of c-Fos-positive cells in the left spinal nucleus of the trigeminus, the bilateral insula, and the bilateral operculum increased in both the deafferentation pain and the MCS groups. There were no statistically significant differences between these groups. In the cingulate gyrus, the percentage of c-Fos-positive cells increased bilaterally in the deafferentation pain group and the MCS group, but the increase was greater in the MCS group. The increase in c-Fos-positive cells in the left spinal nucleus of the trigeminus in the deafferentation group may reflect reported electrical hyperactivity. The cingulate gyrus, insula, and parietal operculum were activated after deafferentation. This change (increase in c-Fos positive cells) is related to the development of deafferentation pain. Pain relief due to MCS is not dependent on the suppression of the activated left spinal nucleus of the trigeminus or the descending analgesic mechanism of the brain stem. Activation of the cingulate gyrus appears to be a factor in the analgesic mechanism of MCS.
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spelling pubmed-45334602015-11-05 The Changes of c-Fos Expression by Motor Cortex Stimulation in the Deafferentation Pain Model KUDO, Kanae TAKAHASHI, Toshio SUZUKI, Shigeharu Neurol Med Chir (Tokyo) Original Article The effect of motor cortex stimulation (MCS) therapy for deafferentation pain was evaluated based on c-Fos, a known pain marker. Nineteen mature cats weighing 1.5–3.5 kg were used. Cats were divided into three groups: a deafferentation pain group in which the left trigeminal ganglion was destroyed, an MCS group in which MCS was used following destruction of the trigeminal ganglion, and a control group. Sites and levels of c-Fos expression were examined immunohistochemically. The percentage of c-Fos-positive cells in the left spinal nucleus of the trigeminus, the bilateral insula, and the bilateral operculum increased in both the deafferentation pain and the MCS groups. There were no statistically significant differences between these groups. In the cingulate gyrus, the percentage of c-Fos-positive cells increased bilaterally in the deafferentation pain group and the MCS group, but the increase was greater in the MCS group. The increase in c-Fos-positive cells in the left spinal nucleus of the trigeminus in the deafferentation group may reflect reported electrical hyperactivity. The cingulate gyrus, insula, and parietal operculum were activated after deafferentation. This change (increase in c-Fos positive cells) is related to the development of deafferentation pain. Pain relief due to MCS is not dependent on the suppression of the activated left spinal nucleus of the trigeminus or the descending analgesic mechanism of the brain stem. Activation of the cingulate gyrus appears to be a factor in the analgesic mechanism of MCS. The Japan Neurosurgical Society 2014-07 2014-06-26 /pmc/articles/PMC4533460/ /pubmed/24965534 http://dx.doi.org/10.2176/nmc.oa.2013-0321 Text en © 2014 The Japan Neurosurgical Society This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/
spellingShingle Original Article
KUDO, Kanae
TAKAHASHI, Toshio
SUZUKI, Shigeharu
The Changes of c-Fos Expression by Motor Cortex Stimulation in the Deafferentation Pain Model
title The Changes of c-Fos Expression by Motor Cortex Stimulation in the Deafferentation Pain Model
title_full The Changes of c-Fos Expression by Motor Cortex Stimulation in the Deafferentation Pain Model
title_fullStr The Changes of c-Fos Expression by Motor Cortex Stimulation in the Deafferentation Pain Model
title_full_unstemmed The Changes of c-Fos Expression by Motor Cortex Stimulation in the Deafferentation Pain Model
title_short The Changes of c-Fos Expression by Motor Cortex Stimulation in the Deafferentation Pain Model
title_sort changes of c-fos expression by motor cortex stimulation in the deafferentation pain model
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4533460/
https://www.ncbi.nlm.nih.gov/pubmed/24965534
http://dx.doi.org/10.2176/nmc.oa.2013-0321
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