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Impact of Bilateral Subthalamic Stimulation on Motor/Cognitive Functions in Parkinson's Disease

It is still unclear whether deep brain stimulation targeted to the bilateral subthalamic nucleus (STN-DBS) affects cognitive function in Parkinson's disease (PD). This prospective study was aimed to systemically evaluate the impact of bilateral STN-DBS on motor and cognitive functions in patien...

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Autores principales: ASAHI, Takashi, NAKAMICHI, Naomi, TAKAIWA, Akiko, KASHIWAZAKI, Daina, KOH, Masaki, DOUGU, Nobuhiro, TAKASHIMA, Shutaro, TANAKA, Kortaro, KURODA, Satoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japan Neurosurgical Society 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4533462/
https://www.ncbi.nlm.nih.gov/pubmed/24872253
http://dx.doi.org/10.2176/nmc.oa.2013-0364
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author ASAHI, Takashi
NAKAMICHI, Naomi
TAKAIWA, Akiko
KASHIWAZAKI, Daina
KOH, Masaki
DOUGU, Nobuhiro
TAKASHIMA, Shutaro
TANAKA, Kortaro
KURODA, Satoshi
author_facet ASAHI, Takashi
NAKAMICHI, Naomi
TAKAIWA, Akiko
KASHIWAZAKI, Daina
KOH, Masaki
DOUGU, Nobuhiro
TAKASHIMA, Shutaro
TANAKA, Kortaro
KURODA, Satoshi
author_sort ASAHI, Takashi
collection PubMed
description It is still unclear whether deep brain stimulation targeted to the bilateral subthalamic nucleus (STN-DBS) affects cognitive function in Parkinson's disease (PD). This prospective study was aimed to systemically evaluate the impact of bilateral STN-DBS on motor and cognitive functions in patients with PD. This study included totally 11 Japanese patients with medically intolerant PD. Neurological and cognitive status was precisely evaluated before and 1 year after bilateral STN-DBS, using unified Parkinson's disease rating scale (UPDRS), levodopa equivalent doses, mini-mental state examination (MMSE), Japanese adult reading test (JART), repeatable battery for the assessment of neuropsychological status (RBANS), and Wechsler adult intelligence scale-revised (WAIS-R). Preoperative RBANS and WAIS-R identified cognitive dysfunction that could not be detected by MMSE and JART. Before surgery, PD patients had significantly impaired immediate memory and attention. Motor function significantly improved 1 year after bilateral STN-DBS. Bilateral STN-DBS did not affect any score on cognitive examinations. However, postoperative improvements of total score on RBANS and performance intelligence quotient (PIQ) scores on WAIS-R were closely related to those of UPDRS part III off (R(2) = 0.61, P < 0.01; R(2) = 0.39, P < 0.05, respectively). These findings strongly suggest that bilateral STN-DBS may significantly improve cognitive function in a certain subgroup of patients whose therapeutic effects on motor function are prominent.
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spelling pubmed-45334622015-11-05 Impact of Bilateral Subthalamic Stimulation on Motor/Cognitive Functions in Parkinson's Disease ASAHI, Takashi NAKAMICHI, Naomi TAKAIWA, Akiko KASHIWAZAKI, Daina KOH, Masaki DOUGU, Nobuhiro TAKASHIMA, Shutaro TANAKA, Kortaro KURODA, Satoshi Neurol Med Chir (Tokyo) Original Article It is still unclear whether deep brain stimulation targeted to the bilateral subthalamic nucleus (STN-DBS) affects cognitive function in Parkinson's disease (PD). This prospective study was aimed to systemically evaluate the impact of bilateral STN-DBS on motor and cognitive functions in patients with PD. This study included totally 11 Japanese patients with medically intolerant PD. Neurological and cognitive status was precisely evaluated before and 1 year after bilateral STN-DBS, using unified Parkinson's disease rating scale (UPDRS), levodopa equivalent doses, mini-mental state examination (MMSE), Japanese adult reading test (JART), repeatable battery for the assessment of neuropsychological status (RBANS), and Wechsler adult intelligence scale-revised (WAIS-R). Preoperative RBANS and WAIS-R identified cognitive dysfunction that could not be detected by MMSE and JART. Before surgery, PD patients had significantly impaired immediate memory and attention. Motor function significantly improved 1 year after bilateral STN-DBS. Bilateral STN-DBS did not affect any score on cognitive examinations. However, postoperative improvements of total score on RBANS and performance intelligence quotient (PIQ) scores on WAIS-R were closely related to those of UPDRS part III off (R(2) = 0.61, P < 0.01; R(2) = 0.39, P < 0.05, respectively). These findings strongly suggest that bilateral STN-DBS may significantly improve cognitive function in a certain subgroup of patients whose therapeutic effects on motor function are prominent. The Japan Neurosurgical Society 2014-07 2014-05-29 /pmc/articles/PMC4533462/ /pubmed/24872253 http://dx.doi.org/10.2176/nmc.oa.2013-0364 Text en © 2014 The Japan Neurosurgical Society This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/
spellingShingle Original Article
ASAHI, Takashi
NAKAMICHI, Naomi
TAKAIWA, Akiko
KASHIWAZAKI, Daina
KOH, Masaki
DOUGU, Nobuhiro
TAKASHIMA, Shutaro
TANAKA, Kortaro
KURODA, Satoshi
Impact of Bilateral Subthalamic Stimulation on Motor/Cognitive Functions in Parkinson's Disease
title Impact of Bilateral Subthalamic Stimulation on Motor/Cognitive Functions in Parkinson's Disease
title_full Impact of Bilateral Subthalamic Stimulation on Motor/Cognitive Functions in Parkinson's Disease
title_fullStr Impact of Bilateral Subthalamic Stimulation on Motor/Cognitive Functions in Parkinson's Disease
title_full_unstemmed Impact of Bilateral Subthalamic Stimulation on Motor/Cognitive Functions in Parkinson's Disease
title_short Impact of Bilateral Subthalamic Stimulation on Motor/Cognitive Functions in Parkinson's Disease
title_sort impact of bilateral subthalamic stimulation on motor/cognitive functions in parkinson's disease
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4533462/
https://www.ncbi.nlm.nih.gov/pubmed/24872253
http://dx.doi.org/10.2176/nmc.oa.2013-0364
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