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Asparaginase treatment side-effects may be due to genes with homopolymeric Asn codons (Review-Hypothesis)
The present treatment of childhood T-cell leukemias involves the systemic administration of prokary-otic L-asparaginase (ASNase), which depletes plasma Asparagine (Asn) and inhibits protein synthesis. The mechanism of therapeutic action of ASNase is poorly understood, as are the etiologies of the si...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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D.A. Spandidos
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4533780/ https://www.ncbi.nlm.nih.gov/pubmed/26178806 http://dx.doi.org/10.3892/ijmm.2015.2285 |