Construction of a recombinant duck enteritis virus (DEV) expressing hemagglutinin of H5N1 avian influenza virus based on an infectious clone of DEV vaccine strain and evaluation of its efficacy in ducks and chickens

BACKGROUND: Highly pathogenic avian influenza virus (AIV) subtype H5N1 remains a threat to poultry. Duck enteritis virus (DEV)-vectored vaccines expressing AIV H5N1 hemagglutinin (HA) may be viable AIV and DEV vaccine candidates. METHODS: To facilitate the generation and further improvement of DEV-v...

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Autores principales: Wang, Jichun, Ge, Aimin, Xu, Mengwei, Wang, Zhisheng, Qiao, Yongfeng, Gu, Yiqi, Liu, Chang, Liu, Yamei, Hou, Jibo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4533785/
https://www.ncbi.nlm.nih.gov/pubmed/26263920
http://dx.doi.org/10.1186/s12985-015-0354-9

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