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Misdiagnosis of inclusion body myositis: two case reports and a retrospective chart review

INTRODUCTION: Sporadic inclusion body myositis is the most common adult myopathy in persons aged 50 years and older. The clinical presentation includes a chronic, slowly progressive course with a predilection for weakness of the forearm flexors and quadriceps muscles. Its indolent course makes it a...

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Autores principales: Chilingaryan, Amaiak, Rison, Richard A., Beydoun, Said R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4533788/
https://www.ncbi.nlm.nih.gov/pubmed/26268316
http://dx.doi.org/10.1186/s13256-015-0647-z
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author Chilingaryan, Amaiak
Rison, Richard A.
Beydoun, Said R.
author_facet Chilingaryan, Amaiak
Rison, Richard A.
Beydoun, Said R.
author_sort Chilingaryan, Amaiak
collection PubMed
description INTRODUCTION: Sporadic inclusion body myositis is the most common adult myopathy in persons aged 50 years and older. The clinical presentation includes a chronic, slowly progressive course with a predilection for weakness of the forearm flexors and quadriceps muscles. Its indolent course makes it a disease frequently missed or misdiagnosed as other neuromuscular conditions by health care professionals. The degenerative processes with amyloid accumulation distinguish sporadic inclusion body myositis from other inflammatory myopathies. Currently, no effective therapy exists. This clinical report highlights the difficulties in diagnosing the disease, examples of misdiagnosis, and inappropriate therapies that can result from misdiagnosis. CASE PRESENTATION: We present our clinical experience with 20 patients over a 10-year period and describe in depth two cases, both men, one of Indian ethnicity and the other of Hispanic ethnicity, who were referred to our neuromuscular division for second opinions and diagnosed with sporadic inclusion body myositis years after symptom onset. CONCLUSIONS: Although sporadic inclusion body myositis is rare and without effective therapy, accurate diagnosis is crucial to providing adequate counseling and information about the prognosis and disease course, and to avoiding inappropriate therapy.
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spelling pubmed-45337882015-08-13 Misdiagnosis of inclusion body myositis: two case reports and a retrospective chart review Chilingaryan, Amaiak Rison, Richard A. Beydoun, Said R. J Med Case Rep Case Report INTRODUCTION: Sporadic inclusion body myositis is the most common adult myopathy in persons aged 50 years and older. The clinical presentation includes a chronic, slowly progressive course with a predilection for weakness of the forearm flexors and quadriceps muscles. Its indolent course makes it a disease frequently missed or misdiagnosed as other neuromuscular conditions by health care professionals. The degenerative processes with amyloid accumulation distinguish sporadic inclusion body myositis from other inflammatory myopathies. Currently, no effective therapy exists. This clinical report highlights the difficulties in diagnosing the disease, examples of misdiagnosis, and inappropriate therapies that can result from misdiagnosis. CASE PRESENTATION: We present our clinical experience with 20 patients over a 10-year period and describe in depth two cases, both men, one of Indian ethnicity and the other of Hispanic ethnicity, who were referred to our neuromuscular division for second opinions and diagnosed with sporadic inclusion body myositis years after symptom onset. CONCLUSIONS: Although sporadic inclusion body myositis is rare and without effective therapy, accurate diagnosis is crucial to providing adequate counseling and information about the prognosis and disease course, and to avoiding inappropriate therapy. BioMed Central 2015-08-13 /pmc/articles/PMC4533788/ /pubmed/26268316 http://dx.doi.org/10.1186/s13256-015-0647-z Text en © Chilingaryan et al. 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Case Report
Chilingaryan, Amaiak
Rison, Richard A.
Beydoun, Said R.
Misdiagnosis of inclusion body myositis: two case reports and a retrospective chart review
title Misdiagnosis of inclusion body myositis: two case reports and a retrospective chart review
title_full Misdiagnosis of inclusion body myositis: two case reports and a retrospective chart review
title_fullStr Misdiagnosis of inclusion body myositis: two case reports and a retrospective chart review
title_full_unstemmed Misdiagnosis of inclusion body myositis: two case reports and a retrospective chart review
title_short Misdiagnosis of inclusion body myositis: two case reports and a retrospective chart review
title_sort misdiagnosis of inclusion body myositis: two case reports and a retrospective chart review
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4533788/
https://www.ncbi.nlm.nih.gov/pubmed/26268316
http://dx.doi.org/10.1186/s13256-015-0647-z
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