SHMT2 drives glioma cell survival in the tumor microenvironment but imposes a dependence on glycine clearance

Cancer cells adapt their metabolic processes to support rapid proliferation, but less is known about how cancer cells alter metabolism to promote cell survival in a poorly vascularized tumor microenvironment(1–3). Here, we identify a key role for serine and glycine metabolism in the survival of brai...

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Detalles Bibliográficos
Autores principales: Kim, Dohoon, Fiske, Brian P., Birsoy, Kivanc, Freinkman, Elizaveta, Kami, Kenjiro, Possemato, Richard, Chudnovsky, Yakov, Pacold, Michael E., Chen, Walter W., Cantor, Jason R., Shelton, Laura M., Gui, Dan Y., Kwon, Manjae, Ramkissoon, Shakti H., Ligon, Keith L., Kang, Seong Woo, Snuderl, Matija, Heiden, Matthew G. Vander, Sabatini, David M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4533874/
https://www.ncbi.nlm.nih.gov/pubmed/25855294
http://dx.doi.org/10.1038/nature14363

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