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Biomarkers to enhance accuracy and precision of prediction of short-term and long-term outcome after spontaneous intracerebral haemorrhage: a study protocol for a prospective cohort study

BACKGROUND: Several studies reported prognostic value of biomarker in intracerebral hemorrhagic (ICH) but they are either preliminary observation or inadequately powered to analyse independent contribution of biomarkers over and above clinical and neuroimaging data. OBJECTIVE: To examine whether the...

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Autores principales: Kumar, A., Kumar, P., Misra, S., Sagar, R., Kathuria, P., Vibha, D., Vivekanandhan, S., Garg, A., Kaul, B., Raghvan, S., Gorthi, S. P., Dabla, S., Aggarwal, C. S., Prasad, Kameshwar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4533964/
https://www.ncbi.nlm.nih.gov/pubmed/26264492
http://dx.doi.org/10.1186/s12883-015-0384-3
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author Kumar, A.
Kumar, P.
Misra, S.
Sagar, R.
Kathuria, P.
Vibha, D.
Vivekanandhan, S.
Garg, A.
Kaul, B.
Raghvan, S.
Gorthi, S. P.
Dabla, S.
Aggarwal, C. S.
Prasad, Kameshwar
author_facet Kumar, A.
Kumar, P.
Misra, S.
Sagar, R.
Kathuria, P.
Vibha, D.
Vivekanandhan, S.
Garg, A.
Kaul, B.
Raghvan, S.
Gorthi, S. P.
Dabla, S.
Aggarwal, C. S.
Prasad, Kameshwar
author_sort Kumar, A.
collection PubMed
description BACKGROUND: Several studies reported prognostic value of biomarker in intracerebral hemorrhagic (ICH) but they are either preliminary observation or inadequately powered to analyse independent contribution of biomarkers over and above clinical and neuroimaging data. OBJECTIVE: To examine whether the biomarker can significantly add to the predictive accuracy of prognosis of ICH. METHOD/DESIGN: In a multi-centric prospective cohort study, 1020 patients with ICH within 72 hours of onset are being recruited. After obtaining written informed consent from patients/proxy, venous blood sample (10 ml) is being collected and analysed for C-reactive protein (CRP) level, S100B, Glial fibrillary acidic protein (GFAP), Troponin, change in leukocyte count and Copeptin levels. The patients are telephonically followed using stroke scales (Barthel Index and modified Rankin Scale) at 3, 6, 12 months and 2 years after the recruitment. DISCUSSION: This protocol will aim at predicting the short term or long term prognosis with the use of clinical, neuroimaging and biomarkers in order to help clinician to stratify patients for early referral or intervention.
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spelling pubmed-45339642015-08-13 Biomarkers to enhance accuracy and precision of prediction of short-term and long-term outcome after spontaneous intracerebral haemorrhage: a study protocol for a prospective cohort study Kumar, A. Kumar, P. Misra, S. Sagar, R. Kathuria, P. Vibha, D. Vivekanandhan, S. Garg, A. Kaul, B. Raghvan, S. Gorthi, S. P. Dabla, S. Aggarwal, C. S. Prasad, Kameshwar BMC Neurol Study Protocol BACKGROUND: Several studies reported prognostic value of biomarker in intracerebral hemorrhagic (ICH) but they are either preliminary observation or inadequately powered to analyse independent contribution of biomarkers over and above clinical and neuroimaging data. OBJECTIVE: To examine whether the biomarker can significantly add to the predictive accuracy of prognosis of ICH. METHOD/DESIGN: In a multi-centric prospective cohort study, 1020 patients with ICH within 72 hours of onset are being recruited. After obtaining written informed consent from patients/proxy, venous blood sample (10 ml) is being collected and analysed for C-reactive protein (CRP) level, S100B, Glial fibrillary acidic protein (GFAP), Troponin, change in leukocyte count and Copeptin levels. The patients are telephonically followed using stroke scales (Barthel Index and modified Rankin Scale) at 3, 6, 12 months and 2 years after the recruitment. DISCUSSION: This protocol will aim at predicting the short term or long term prognosis with the use of clinical, neuroimaging and biomarkers in order to help clinician to stratify patients for early referral or intervention. BioMed Central 2015-08-12 /pmc/articles/PMC4533964/ /pubmed/26264492 http://dx.doi.org/10.1186/s12883-015-0384-3 Text en © Kumar et al. 2015 Open Access This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Study Protocol
Kumar, A.
Kumar, P.
Misra, S.
Sagar, R.
Kathuria, P.
Vibha, D.
Vivekanandhan, S.
Garg, A.
Kaul, B.
Raghvan, S.
Gorthi, S. P.
Dabla, S.
Aggarwal, C. S.
Prasad, Kameshwar
Biomarkers to enhance accuracy and precision of prediction of short-term and long-term outcome after spontaneous intracerebral haemorrhage: a study protocol for a prospective cohort study
title Biomarkers to enhance accuracy and precision of prediction of short-term and long-term outcome after spontaneous intracerebral haemorrhage: a study protocol for a prospective cohort study
title_full Biomarkers to enhance accuracy and precision of prediction of short-term and long-term outcome after spontaneous intracerebral haemorrhage: a study protocol for a prospective cohort study
title_fullStr Biomarkers to enhance accuracy and precision of prediction of short-term and long-term outcome after spontaneous intracerebral haemorrhage: a study protocol for a prospective cohort study
title_full_unstemmed Biomarkers to enhance accuracy and precision of prediction of short-term and long-term outcome after spontaneous intracerebral haemorrhage: a study protocol for a prospective cohort study
title_short Biomarkers to enhance accuracy and precision of prediction of short-term and long-term outcome after spontaneous intracerebral haemorrhage: a study protocol for a prospective cohort study
title_sort biomarkers to enhance accuracy and precision of prediction of short-term and long-term outcome after spontaneous intracerebral haemorrhage: a study protocol for a prospective cohort study
topic Study Protocol
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4533964/
https://www.ncbi.nlm.nih.gov/pubmed/26264492
http://dx.doi.org/10.1186/s12883-015-0384-3
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