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Changepoint detection in base-resolution methylome data reveals a robust signature of methylated domain landscape
BACKGROUND: Base-resolution methylome data generated by whole-genome bisulfite sequencing (WGBS) is often used to segment the genome into domains with distinct methylation levels. However, most segmentation methods include many parameters to be carefully tuned and/or fail to exploit the unsurpassed...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4534107/ https://www.ncbi.nlm.nih.gov/pubmed/26265481 http://dx.doi.org/10.1186/s12864-015-1809-5 |