Cargando…
Daily consumption of a mangosteen-based drink improves in vivo antioxidant and anti-inflammatory biomarkers in healthy adults: a randomized, double-blind, placebo-controlled clinical trial
Mangosteen (Garcinia mangostana) is a tropical fruit cultivated mainly in Southeast Asia. Recent studies have shown mangosteen has many health benefits. In this study, we aimed to determine the effects of a mangosteen-based beverage on antioxidant and anti-inflammatory and immunity biomarkers in pla...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons, Ltd
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4534161/ https://www.ncbi.nlm.nih.gov/pubmed/26286710 http://dx.doi.org/10.1002/fsn3.225 |
_version_ | 1782385425237671936 |
---|---|
author | Xie, Zhuohong Sintara, Marsha Chang, Tony Ou, Boxin |
author_facet | Xie, Zhuohong Sintara, Marsha Chang, Tony Ou, Boxin |
author_sort | Xie, Zhuohong |
collection | PubMed |
description | Mangosteen (Garcinia mangostana) is a tropical fruit cultivated mainly in Southeast Asia. Recent studies have shown mangosteen has many health benefits. In this study, we aimed to determine the effects of a mangosteen-based beverage on antioxidant and anti-inflammatory and immunity biomarkers in plasma of healthy adults. A randomized, double-blind, placebo-controlled clinical trial was conducted using 60 participants, 30 men, and 30 women, ages 18–60. Participants were randomly divided into two groups, placebo and mangosteen groups, with the same number of male and female participants in each group. The trial duration was 30 days. ORAC as an antioxidant biomarker was measured in both groups. It was found that after the 30-day trial, the group given the mangosteen-based drink formula showed 15% more antioxidant capacity in the bloodstream than did the placebo group. As for the inflammatory biomarkers, in the mangosteen group, between the preintervention and postintervention, the C-reactive protein level significantly decreased by 46%, while no significant decreases for the same biomarker was observed in the placebo group. Immunity biomarkers IgA, IgG, IgM, C3 and C4 were not affected in either group. In addition, the effects on hepatic function (Aspartate Aminotransferase and Alanine Aminotransferase) and kidney function (creatinine) were investigated. Our results indicated that after the 30-day consumption of the beverage, there were no side effects on human hepatic and kidney functions. The outcome of this study showed that the mangosteen-based formula significantly increases antioxidant capacity and possesses anti-inflammatory benefits with no side effects on immune, hepatic, and renal functions for long-term consumption. |
format | Online Article Text |
id | pubmed-4534161 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | John Wiley & Sons, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-45341612015-08-18 Daily consumption of a mangosteen-based drink improves in vivo antioxidant and anti-inflammatory biomarkers in healthy adults: a randomized, double-blind, placebo-controlled clinical trial Xie, Zhuohong Sintara, Marsha Chang, Tony Ou, Boxin Food Sci Nutr Original Research Mangosteen (Garcinia mangostana) is a tropical fruit cultivated mainly in Southeast Asia. Recent studies have shown mangosteen has many health benefits. In this study, we aimed to determine the effects of a mangosteen-based beverage on antioxidant and anti-inflammatory and immunity biomarkers in plasma of healthy adults. A randomized, double-blind, placebo-controlled clinical trial was conducted using 60 participants, 30 men, and 30 women, ages 18–60. Participants were randomly divided into two groups, placebo and mangosteen groups, with the same number of male and female participants in each group. The trial duration was 30 days. ORAC as an antioxidant biomarker was measured in both groups. It was found that after the 30-day trial, the group given the mangosteen-based drink formula showed 15% more antioxidant capacity in the bloodstream than did the placebo group. As for the inflammatory biomarkers, in the mangosteen group, between the preintervention and postintervention, the C-reactive protein level significantly decreased by 46%, while no significant decreases for the same biomarker was observed in the placebo group. Immunity biomarkers IgA, IgG, IgM, C3 and C4 were not affected in either group. In addition, the effects on hepatic function (Aspartate Aminotransferase and Alanine Aminotransferase) and kidney function (creatinine) were investigated. Our results indicated that after the 30-day consumption of the beverage, there were no side effects on human hepatic and kidney functions. The outcome of this study showed that the mangosteen-based formula significantly increases antioxidant capacity and possesses anti-inflammatory benefits with no side effects on immune, hepatic, and renal functions for long-term consumption. John Wiley & Sons, Ltd 2015-07 2015-04-13 /pmc/articles/PMC4534161/ /pubmed/26286710 http://dx.doi.org/10.1002/fsn3.225 Text en © 2015 The Authors. Food Science & Nutrition published by Wiley Periodicals, Inc. http://creativecommons.org/licenses/by/4.0/ This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Research Xie, Zhuohong Sintara, Marsha Chang, Tony Ou, Boxin Daily consumption of a mangosteen-based drink improves in vivo antioxidant and anti-inflammatory biomarkers in healthy adults: a randomized, double-blind, placebo-controlled clinical trial |
title | Daily consumption of a mangosteen-based drink improves in vivo antioxidant and anti-inflammatory biomarkers in healthy adults: a randomized, double-blind, placebo-controlled clinical trial |
title_full | Daily consumption of a mangosteen-based drink improves in vivo antioxidant and anti-inflammatory biomarkers in healthy adults: a randomized, double-blind, placebo-controlled clinical trial |
title_fullStr | Daily consumption of a mangosteen-based drink improves in vivo antioxidant and anti-inflammatory biomarkers in healthy adults: a randomized, double-blind, placebo-controlled clinical trial |
title_full_unstemmed | Daily consumption of a mangosteen-based drink improves in vivo antioxidant and anti-inflammatory biomarkers in healthy adults: a randomized, double-blind, placebo-controlled clinical trial |
title_short | Daily consumption of a mangosteen-based drink improves in vivo antioxidant and anti-inflammatory biomarkers in healthy adults: a randomized, double-blind, placebo-controlled clinical trial |
title_sort | daily consumption of a mangosteen-based drink improves in vivo antioxidant and anti-inflammatory biomarkers in healthy adults: a randomized, double-blind, placebo-controlled clinical trial |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4534161/ https://www.ncbi.nlm.nih.gov/pubmed/26286710 http://dx.doi.org/10.1002/fsn3.225 |
work_keys_str_mv | AT xiezhuohong dailyconsumptionofamangosteenbaseddrinkimprovesinvivoantioxidantandantiinflammatorybiomarkersinhealthyadultsarandomizeddoubleblindplacebocontrolledclinicaltrial AT sintaramarsha dailyconsumptionofamangosteenbaseddrinkimprovesinvivoantioxidantandantiinflammatorybiomarkersinhealthyadultsarandomizeddoubleblindplacebocontrolledclinicaltrial AT changtony dailyconsumptionofamangosteenbaseddrinkimprovesinvivoantioxidantandantiinflammatorybiomarkersinhealthyadultsarandomizeddoubleblindplacebocontrolledclinicaltrial AT ouboxin dailyconsumptionofamangosteenbaseddrinkimprovesinvivoantioxidantandantiinflammatorybiomarkersinhealthyadultsarandomizeddoubleblindplacebocontrolledclinicaltrial |