Loss-of-Function PTPRD Mutations Lead to Increased STAT3 Activation and Sensitivity to STAT3 Inhibition in Head and Neck Cancer

BACKGROUND: Protein tyrosine phosphatase receptor type D (PTPRD) is a putative tumor suppressor in several cancers including head and neck squamous cell carcinoma (HNSCC). STAT3 is a frequently hyperactivated oncogene in HNSCC. As STAT3 is a direct substrate of PTPRD, we sought to determine the gene...

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Detalles Bibliográficos
Autores principales: Peyser, Noah D., Du, Yu, Li, Hua, Lui, Vivian, Xiao, Xiao, Chan, Timothy A., Grandis, Jennifer R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4534317/
https://www.ncbi.nlm.nih.gov/pubmed/26267899
http://dx.doi.org/10.1371/journal.pone.0135750

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