The Dnmt3L ADD Domain Controls Cytosine Methylation Establishment during Spermatogenesis

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A critical aspect of mammalian gametogenesis is the reprogramming of genomic DNA methylation. The catalytically inactive adaptor Dnmt3L is essential to ensuring this occurs correctly, but the mechanism by which it functions is unclear. Using gene targeting to engineer a single-amino-acid mutation, w...

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Detalles Bibliográficos
Autores principales: Vlachogiannis, Georgios, Niederhuth, Chad E., Tuna, Salih, Stathopoulou, Athanasia, Viiri, Keijo, de Rooij, Dirk G., Jenner, Richard G., Schmitz, Robert J., Ooi, Steen K.T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4534369/
https://www.ncbi.nlm.nih.gov/pubmed/25683717
http://dx.doi.org/10.1016/j.celrep.2015.01.021
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