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Clinical features and prognosis of prostate cancer with high-grade prostatic intraepithelial neoplasia

PURPOSE: To evaluate the clinical features and biochemical recurrence (BCR) in prostate cancer (PCa) with high-grade prostatic intraepithelial neoplasia (HGPIN). MATERIALS AND METHODS: We retrospectively analyzed the medical records of 893 patients who underwent a radical prostatectomy for PCa betwe...

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Autores principales: Lee, Donghyun, Lee, Chunwoo, Kwon, Taekmin, You, Dalsan, Jeong, In Gab, Hong, Jun Hyuk, Ahn, Hanjong, Kim, Choung-Soo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Urological Association 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4534430/
https://www.ncbi.nlm.nih.gov/pubmed/26279825
http://dx.doi.org/10.4111/kju.2015.56.8.565
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author Lee, Donghyun
Lee, Chunwoo
Kwon, Taekmin
You, Dalsan
Jeong, In Gab
Hong, Jun Hyuk
Ahn, Hanjong
Kim, Choung-Soo
author_facet Lee, Donghyun
Lee, Chunwoo
Kwon, Taekmin
You, Dalsan
Jeong, In Gab
Hong, Jun Hyuk
Ahn, Hanjong
Kim, Choung-Soo
author_sort Lee, Donghyun
collection PubMed
description PURPOSE: To evaluate the clinical features and biochemical recurrence (BCR) in prostate cancer (PCa) with high-grade prostatic intraepithelial neoplasia (HGPIN). MATERIALS AND METHODS: We retrospectively analyzed the medical records of 893 patients who underwent a radical prostatectomy for PCa between 2011 and 2012 at Asan Medical Center; 752 of these patients who did not receive neoadjuvant or adjuvant therapy and were followed up for more than 1 year were included. The cohort was divided into two groups-patients with and without HGPIN-and their characteristics were compared. The Cox proportional hazards model was used to analyze factors affecting BCR. RESULTS: In total, 652 study patients (86.7%) had HGPIN. There were no significant differences in preoperative factors between the two groups, including age (p=0.369) and preoperative prostate-specific antigen concentration (p=0.234). Patients with HGPIN had a higher Gleason score (p=0.012), more frequent multiple tumor (p=0.013), and more perineural invasion (p=0.012), but no other postoperative pathologic characteristics were significantly different between the two groups. There were no significant differences in BCR (13.0% vs. 11.5%, p=0.665) and HGPIN was not associated with BCR (p=0.745). In multivariate analysis, only the T stage (p<0.001) was associated with BCR. CONCLUSIONS: PCa patients with HGPIN have a higher Gleason score, more frequent multiple tumors, and more perineural invasion than those without HGPIN. The presence of HGPIN is not an independent predictor of BCR.
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spelling pubmed-45344302015-08-16 Clinical features and prognosis of prostate cancer with high-grade prostatic intraepithelial neoplasia Lee, Donghyun Lee, Chunwoo Kwon, Taekmin You, Dalsan Jeong, In Gab Hong, Jun Hyuk Ahn, Hanjong Kim, Choung-Soo Korean J Urol Original Article PURPOSE: To evaluate the clinical features and biochemical recurrence (BCR) in prostate cancer (PCa) with high-grade prostatic intraepithelial neoplasia (HGPIN). MATERIALS AND METHODS: We retrospectively analyzed the medical records of 893 patients who underwent a radical prostatectomy for PCa between 2011 and 2012 at Asan Medical Center; 752 of these patients who did not receive neoadjuvant or adjuvant therapy and were followed up for more than 1 year were included. The cohort was divided into two groups-patients with and without HGPIN-and their characteristics were compared. The Cox proportional hazards model was used to analyze factors affecting BCR. RESULTS: In total, 652 study patients (86.7%) had HGPIN. There were no significant differences in preoperative factors between the two groups, including age (p=0.369) and preoperative prostate-specific antigen concentration (p=0.234). Patients with HGPIN had a higher Gleason score (p=0.012), more frequent multiple tumor (p=0.013), and more perineural invasion (p=0.012), but no other postoperative pathologic characteristics were significantly different between the two groups. There were no significant differences in BCR (13.0% vs. 11.5%, p=0.665) and HGPIN was not associated with BCR (p=0.745). In multivariate analysis, only the T stage (p<0.001) was associated with BCR. CONCLUSIONS: PCa patients with HGPIN have a higher Gleason score, more frequent multiple tumors, and more perineural invasion than those without HGPIN. The presence of HGPIN is not an independent predictor of BCR. The Korean Urological Association 2015-08 2015-07-24 /pmc/articles/PMC4534430/ /pubmed/26279825 http://dx.doi.org/10.4111/kju.2015.56.8.565 Text en © The Korean Urological Association, 2015 http://creativecommons.org/licenses/by-nc/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Lee, Donghyun
Lee, Chunwoo
Kwon, Taekmin
You, Dalsan
Jeong, In Gab
Hong, Jun Hyuk
Ahn, Hanjong
Kim, Choung-Soo
Clinical features and prognosis of prostate cancer with high-grade prostatic intraepithelial neoplasia
title Clinical features and prognosis of prostate cancer with high-grade prostatic intraepithelial neoplasia
title_full Clinical features and prognosis of prostate cancer with high-grade prostatic intraepithelial neoplasia
title_fullStr Clinical features and prognosis of prostate cancer with high-grade prostatic intraepithelial neoplasia
title_full_unstemmed Clinical features and prognosis of prostate cancer with high-grade prostatic intraepithelial neoplasia
title_short Clinical features and prognosis of prostate cancer with high-grade prostatic intraepithelial neoplasia
title_sort clinical features and prognosis of prostate cancer with high-grade prostatic intraepithelial neoplasia
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4534430/
https://www.ncbi.nlm.nih.gov/pubmed/26279825
http://dx.doi.org/10.4111/kju.2015.56.8.565
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