Orthology for comparative genomics in the mouse genome database

The mouse genome database (MGD) is the model organism database component of the mouse genome informatics system at The Jackson Laboratory. MGD is the international data resource for the laboratory mouse and facilitates the use of mice in the study of human health and disease. Since its beginnings, M...

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Autores principales: Dolan, Mary E., Baldarelli, Richard M., Bello, Susan M., Ni, Li, McAndrews, Monica S., Bult, Carol J., Kadin, James A., Richardson, Joel E., Ringwald, Martin, Eppig, Janan T., Blake, Judith A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4534493/
https://www.ncbi.nlm.nih.gov/pubmed/26223881
http://dx.doi.org/10.1007/s00335-015-9588-5
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author Dolan, Mary E.
Baldarelli, Richard M.
Bello, Susan M.
Ni, Li
McAndrews, Monica S.
Bult, Carol J.
Kadin, James A.
Richardson, Joel E.
Ringwald, Martin
Eppig, Janan T.
Blake, Judith A.
author_facet Dolan, Mary E.
Baldarelli, Richard M.
Bello, Susan M.
Ni, Li
McAndrews, Monica S.
Bult, Carol J.
Kadin, James A.
Richardson, Joel E.
Ringwald, Martin
Eppig, Janan T.
Blake, Judith A.
author_sort Dolan, Mary E.
collection PubMed
description The mouse genome database (MGD) is the model organism database component of the mouse genome informatics system at The Jackson Laboratory. MGD is the international data resource for the laboratory mouse and facilitates the use of mice in the study of human health and disease. Since its beginnings, MGD has included comparative genomics data with a particular focus on human–mouse orthology, an essential component of the use of mouse as a model organism. Over the past 25 years, novel algorithms and addition of orthologs from other model organisms have enriched comparative genomics in MGD data, extending the use of orthology data to support the laboratory mouse as a model of human biology. Here, we describe current comparative data in MGD and review the history and refinement of orthology representation in this resource.
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spelling pubmed-45344932015-08-20 Orthology for comparative genomics in the mouse genome database Dolan, Mary E. Baldarelli, Richard M. Bello, Susan M. Ni, Li McAndrews, Monica S. Bult, Carol J. Kadin, James A. Richardson, Joel E. Ringwald, Martin Eppig, Janan T. Blake, Judith A. Mamm Genome Article The mouse genome database (MGD) is the model organism database component of the mouse genome informatics system at The Jackson Laboratory. MGD is the international data resource for the laboratory mouse and facilitates the use of mice in the study of human health and disease. Since its beginnings, MGD has included comparative genomics data with a particular focus on human–mouse orthology, an essential component of the use of mouse as a model organism. Over the past 25 years, novel algorithms and addition of orthologs from other model organisms have enriched comparative genomics in MGD data, extending the use of orthology data to support the laboratory mouse as a model of human biology. Here, we describe current comparative data in MGD and review the history and refinement of orthology representation in this resource. Springer US 2015-07-30 2015 /pmc/articles/PMC4534493/ /pubmed/26223881 http://dx.doi.org/10.1007/s00335-015-9588-5 Text en © The Author(s) 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Article
Dolan, Mary E.
Baldarelli, Richard M.
Bello, Susan M.
Ni, Li
McAndrews, Monica S.
Bult, Carol J.
Kadin, James A.
Richardson, Joel E.
Ringwald, Martin
Eppig, Janan T.
Blake, Judith A.
Orthology for comparative genomics in the mouse genome database
title Orthology for comparative genomics in the mouse genome database
title_full Orthology for comparative genomics in the mouse genome database
title_fullStr Orthology for comparative genomics in the mouse genome database
title_full_unstemmed Orthology for comparative genomics in the mouse genome database
title_short Orthology for comparative genomics in the mouse genome database
title_sort orthology for comparative genomics in the mouse genome database
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4534493/
https://www.ncbi.nlm.nih.gov/pubmed/26223881
http://dx.doi.org/10.1007/s00335-015-9588-5
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