Bortezomib Amplifies Effect on Intracellular Proteasomes by Changing Proteasome Structure()

The proteasome inhibitor Bortezomib is used to treat multiple myeloma (MM). Bortezomib inhibits protein degradation by inactivating proteasomes' active-sites. MM cells are exquisitely sensitive to Bortezomib – exhibiting a low-nanomolar IC(50) – suggesting that minimal inhibition of degradation...

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Detalles Bibliográficos
Autores principales: Pitcher, David S., de Mattos-Shipley, Kate, Tzortzis, Konstantinos, Auner, Holger W., Karadimitris, Anastasios, Kleijnen, Maurits F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4534688/
https://www.ncbi.nlm.nih.gov/pubmed/26288836
http://dx.doi.org/10.1016/j.ebiom.2015.05.016

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4534688/
https://www.ncbi.nlm.nih.gov/pubmed/26288836
http://dx.doi.org/10.1016/j.ebiom.2015.05.016

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