Loss of photoreceptorness and gain of genomic alterations in retinoblastoma reveal tumor progression

BACKGROUND: Retinoblastoma is a pediatric eye cancer associated with RB1 loss or MYCN amplification (RB1(+/+)MYCN(A)). There are controversies concerning the existence of molecular subtypes within RB1(−/−) retinoblastoma. To test whether these molecular subtypes exist, we performed molecular profili...

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Detalles Bibliográficos
Autores principales: Kooi, Irsan E., Mol, Berber M., Moll, Annette C., van der Valk, Paul, de Jong, Marcus C., de Graaf, Pim, van Mil, Saskia E., Schouten-van Meeteren, Antoinette Y.N., Meijers-Heijboer, Hanne, Kaspers, Gertjan L., te Riele, Hein, Cloos, Jacqueline, Dorsman, Josephine C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4534696/
https://www.ncbi.nlm.nih.gov/pubmed/26288838
http://dx.doi.org/10.1016/j.ebiom.2015.06.022

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