The selective post-translational processing of transcription factor Nrf1 yields distinct isoforms that dictate its ability to differentially regulate gene expression

Upon translation, the N-terminal homology box 1 (NHB1) signal anchor sequence of Nrf1 integrates it within the endoplasmic reticulum (ER) whilst its transactivation domains [TADs, including acidic domain 1 (AD1), the flanking Asn/Ser/Thr-rich (NST) domain and AD2] are transiently translocated into t...

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Detalles Bibliográficos
Autores principales: Zhang, Yiguo, Li, Shaojun, Xiang, Yuancai, Qiu, Lu, Zhao, Huakan, Hayes, John D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4534795/
https://www.ncbi.nlm.nih.gov/pubmed/26268886
http://dx.doi.org/10.1038/srep12983

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4534795/
https://www.ncbi.nlm.nih.gov/pubmed/26268886
http://dx.doi.org/10.1038/srep12983

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