RXFP1 is Targeted by Complement C1q Tumor Necrosis Factor-Related Factor 8 in Brain Cancer

The relaxin-like RXFP1 ligand–receptor system has important functions in tumor growth and tissue invasion. Recently, we have identified the secreted protein, CTRP8, a member of the C1q/tumor necrosis factor-related protein (CTRP) family, as a novel ligand of the relaxin receptor, RXFP1, with functio...

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Autores principales: Thanasupawat, Thatchawan, Glogowska, Aleksandra, Burg, Maxwell, Wong, G. William, Hoang-Vu, Cuong, Hombach-Klonisch, Sabine, Klonisch, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4534857/
https://www.ncbi.nlm.nih.gov/pubmed/26322020
http://dx.doi.org/10.3389/fendo.2015.00127
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author Thanasupawat, Thatchawan
Glogowska, Aleksandra
Burg, Maxwell
Wong, G. William
Hoang-Vu, Cuong
Hombach-Klonisch, Sabine
Klonisch, Thomas
author_facet Thanasupawat, Thatchawan
Glogowska, Aleksandra
Burg, Maxwell
Wong, G. William
Hoang-Vu, Cuong
Hombach-Klonisch, Sabine
Klonisch, Thomas
author_sort Thanasupawat, Thatchawan
collection PubMed
description The relaxin-like RXFP1 ligand–receptor system has important functions in tumor growth and tissue invasion. Recently, we have identified the secreted protein, CTRP8, a member of the C1q/tumor necrosis factor-related protein (CTRP) family, as a novel ligand of the relaxin receptor, RXFP1, with functions in brain cancer. Here, we review the role of CTRP members in cancers cells with particular emphasis on CTRP8 in glioblastoma.
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spelling pubmed-45348572015-08-28 RXFP1 is Targeted by Complement C1q Tumor Necrosis Factor-Related Factor 8 in Brain Cancer Thanasupawat, Thatchawan Glogowska, Aleksandra Burg, Maxwell Wong, G. William Hoang-Vu, Cuong Hombach-Klonisch, Sabine Klonisch, Thomas Front Endocrinol (Lausanne) Endocrinology The relaxin-like RXFP1 ligand–receptor system has important functions in tumor growth and tissue invasion. Recently, we have identified the secreted protein, CTRP8, a member of the C1q/tumor necrosis factor-related protein (CTRP) family, as a novel ligand of the relaxin receptor, RXFP1, with functions in brain cancer. Here, we review the role of CTRP members in cancers cells with particular emphasis on CTRP8 in glioblastoma. Frontiers Media S.A. 2015-08-13 /pmc/articles/PMC4534857/ /pubmed/26322020 http://dx.doi.org/10.3389/fendo.2015.00127 Text en Copyright © 2015 Thanasupawat, Glogowska, Burg, Wong, Hoang-Vu, Hombach-Klonisch and Klonisch. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Thanasupawat, Thatchawan
Glogowska, Aleksandra
Burg, Maxwell
Wong, G. William
Hoang-Vu, Cuong
Hombach-Klonisch, Sabine
Klonisch, Thomas
RXFP1 is Targeted by Complement C1q Tumor Necrosis Factor-Related Factor 8 in Brain Cancer
title RXFP1 is Targeted by Complement C1q Tumor Necrosis Factor-Related Factor 8 in Brain Cancer
title_full RXFP1 is Targeted by Complement C1q Tumor Necrosis Factor-Related Factor 8 in Brain Cancer
title_fullStr RXFP1 is Targeted by Complement C1q Tumor Necrosis Factor-Related Factor 8 in Brain Cancer
title_full_unstemmed RXFP1 is Targeted by Complement C1q Tumor Necrosis Factor-Related Factor 8 in Brain Cancer
title_short RXFP1 is Targeted by Complement C1q Tumor Necrosis Factor-Related Factor 8 in Brain Cancer
title_sort rxfp1 is targeted by complement c1q tumor necrosis factor-related factor 8 in brain cancer
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4534857/
https://www.ncbi.nlm.nih.gov/pubmed/26322020
http://dx.doi.org/10.3389/fendo.2015.00127
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